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Solubility-pH profiles of a free base and its salt: sibutramine as a case study

Author

Lucero Borja, Diego Sebastián

Castilla, Òscar

Barbas Cañero, Rafael

Subirats i Vila, Xavier

Ràfols Llach, Clara

Publication date

2022-04-13T15:56:12Z

2022-04-13T15:56:12Z

2017-12-24

2022-04-13T15:56:12Z

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Abstract

In the present study the solubility-pH profiles of sibutramine free base and its hydrochloride salt were determined in the pH range between 2.0 and 9.5 by means of the recommended shake-flask method, and the solids collected were dried and studied by X-ray diffraction in order to elucidate their free base or salt structure. Above pHmax (or Gibbs pKa) the solid collected was always identified as free base, whatever the sibutramine species (free base or hydrochloride salt) initially solved. However, in the pH range below pHmax different solids were isolated depending on the buffers employed.

Document Type

Article

Published version

Language

English

Subjects and keywords

Solubilitat; Sals; Potenciometria; Solubility; Salts; Potentiometry

Publisher

IAPC Publishing

Related items

Reproducció del document publicat a: https://doi.org/10.5599/admet.5.4.452

ADMET & DMPK, 2017, vol. 5, num. 4, p. 253-256

https://doi.org/10.5599/admet.5.4.452

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Rights

cc-by (c) Lucero Borja, Diego Sebastián et al., 2017

https://creativecommons.org/licenses/by/4.0/

This item appears in the following Collection(s)

Enginyeria Química i Química Analítica [790]

Institut de Biomedicina (IBUB) [330]

ISGlobal - Institut de Salut Global de Barcelona [60793]