dc.contributor.author
Lucero Borja, Diego Sebastián
dc.contributor.author
Castilla, Òscar
dc.contributor.author
Barbas Cañero, Rafael
dc.contributor.author
Subirats i Vila, Xavier
dc.contributor.author
Ràfols Llach, Clara
dc.date.issued
2022-04-13T15:56:12Z
dc.date.issued
2022-04-13T15:56:12Z
dc.date.issued
2017-12-24
dc.date.issued
2022-04-13T15:56:12Z
dc.identifier
https://hdl.handle.net/2445/184906
dc.description.abstract
In the present study the solubility-pH profiles of sibutramine free base and its hydrochloride salt were determined in the pH range between 2.0 and 9.5 by means of the recommended shake-flask method, and the solids collected were dried and studied by X-ray diffraction in order to elucidate their free base or salt structure. Above pHmax (or Gibbs pKa) the solid collected was always identified as free base, whatever the sibutramine species (free base or hydrochloride salt) initially solved. However, in the pH range below pHmax different solids were isolated depending on the buffers employed.
dc.format
application/pdf
dc.publisher
IAPC Publishing
dc.relation
Reproducció del document publicat a: https://doi.org/10.5599/admet.5.4.452
dc.relation
ADMET & DMPK, 2017, vol. 5, num. 4, p. 253-256
dc.relation
https://doi.org/10.5599/admet.5.4.452
dc.rights
cc-by (c) Lucero Borja, Diego Sebastián et al., 2017
dc.rights
https://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Enginyeria Química i Química Analítica)
dc.subject
Potenciometria
dc.title
Solubility-pH profiles of a free base and its salt: sibutramine as a case study
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
