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Solubility-pH profiles of a free base and its salt: sibutramine as a case study

Autor/a

Lucero Borja, Diego Sebastián

Castilla, Òscar

Barbas Cañero, Rafael

Subirats i Vila, Xavier

Ràfols Llach, Clara

Data de publicació

2022-04-13T15:56:12Z

2022-04-13T15:56:12Z

2017-12-24

2022-04-13T15:56:12Z

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Resum

In the present study the solubility-pH profiles of sibutramine free base and its hydrochloride salt were determined in the pH range between 2.0 and 9.5 by means of the recommended shake-flask method, and the solids collected were dried and studied by X-ray diffraction in order to elucidate their free base or salt structure. Above pHmax (or Gibbs pKa) the solid collected was always identified as free base, whatever the sibutramine species (free base or hydrochloride salt) initially solved. However, in the pH range below pHmax different solids were isolated depending on the buffers employed.

Tipus de document

Article

Versió publicada

Llengua

Anglès

Matèries i paraules clau

Solubilitat; Sals; Potenciometria; Solubility; Salts; Potentiometry

Publicat per

IAPC Publishing

Documents relacionats

Reproducció del document publicat a: https://doi.org/10.5599/admet.5.4.452

ADMET & DMPK, 2017, vol. 5, num. 4, p. 253-256

https://doi.org/10.5599/admet.5.4.452

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Drets

cc-by (c) Lucero Borja, Diego Sebastián et al., 2017

https://creativecommons.org/licenses/by/4.0/

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