Patologia i Terapèutica Experimental: Recent submissions
Now showing items 41-60 of 1057
A new cognitive evaluation battery for Down syndrome and its relevance for clinical trials
The recent prospect of pharmaceutical interventions for cognitive impairment of Down syndrome (DS) has boosted a number of clinical trials in this population. However, running the trials has raised some methodological ...
Transfer of penicillin resistance between Neisseriae in microcosm
Horizontal gene transfer between commensal and pathogenic Neisseriae is the mechanism proposed to explain how pathogenic species acquire altered portions of the penA gene, which encodes penicillin binding protein 2. These ...
Mitotic cell rounding and epithelial thinning regulate lumen growth and shape
Many organ functions rely on epithelial cavities with particular shapes. Morphogenetic anomalies in these cavities lead to kidney, brain or inner ear diseases. Despite their relevance, the mechanisms regulating lumen ...
Membrana neuronal y envejecimiento: aspectos electrofisiológicos
Introducción: las membranas celulares están formadas por lípidos y proteínas. Por su naturaleza hidrofóbica, los fosfolípidos aíslan el medio intracelular y el extracelular. Desarrollo: el medio extracelular es una solución ...
e-Learning en Farmacologia. Resultats de l'aplicació d'una nova metodologia
L'objectiu d'aquest estudi és desenvolupar estratègies per realitzar una docència funcional a Farmacologia. S'ha implementat una nova activitat d'e-Learning basada en unitats temàtiques (UT) mitjançant les quals els ...
El cuestionario-historia-clínica informatizado: entrada, ensayo de viabilidad y estructuración de la información en A.E.D.M.I.
Se presenta un cuestionario-historia clínica informatizado para la creación de dos bases de datos, una de hechos clínicos y otra de conocimentos médicos, adaptadas al Programa AEDMI. Facilita además automática e inmediatamente ...
The serine protease inhibitor neuroserpin is required for normal synaptic plasticity and regulates learning and social behavior
The serine protease inhibitor neuroserpin regulates the activity of tissue-type plasminogen activator (tPA) in the nervous system. Neuroserpin expression is particularly prominent at late stages of neuronal development in ...
Individual epidermal growth factor receptor autophosphorylation sites do not stringently define association motifs for several SH2-containing proteins
To determine whether individual autophosphorylation sites in the epidermal growth factor (EGF) receptor define specific interaction sites for the in vivo association of signal transduction proteins that contain src homology ...
Functional and radiographic outcomes of hallux valgus correction by mini-invasive surgery with Reverdin-Isham and Akin percutaneous osteotomies: a longitudinal prospective study with a 48-month follow-up
Background: Minimally invasive surgery (MIS) represents one of the most innovative surgical treatments of hallux valgus (HV). However, long-term outcomes still remain a matter of discussion within the orthopaedic community. ...
A potent fluorescent transmembrane HCl transporter perturbs cellular pH and promotes cancer cell death
A series of fluorescent coumarin bis-ureas 1-4 have been synthesised, and their anion transport properties studied. The compounds function as highly potent HCl co-transport agents in lipid bilayer membranes. Single crystal ...
Neuropatía amiloidea primitiva en su forma espontánea
La neuropatía amiloidea es una afección rara y no se observa, prácticamente, más que en la amiloidosis primitiva generalizada. En los enfermos afectos de amiloidosis secundaria es excepcional la expresión clínica de ...
Targeting striatal metabotropic glutamate receptor type 5 in Parkinson's disease: bridging molecular studies and clinical trials
Metabotropic glutamate (mGlu) receptors are G protein-coupled receptors expressed primarily on neurons and glial cells modulating the effects of glutamatergic neurotransmission. The pharmacological manipulation of these ...
Melatonin inhibits glucocorticoid receptor nuclear translocation in mouse thymocytes
The antiapoptotic effect of melatonin (MEL) has been described in several systems. In particular, MEL inhibits glucocorticoid-mediated apoptosis. Our group previously demonstrated that in the thymus, MEL inhibits the release ...
The present and future of prostate cancer urine biomarkers
In order to successfully cure patients with prostate cancer (PCa), it is important to detect the disease at an early stage. The existing clinical biomarkers for PCa are not ideal, since they cannot specifically differentiate ...
Identificação de alvos terapêuticos e de diagnóstico através do yeast two hybrid system: a biologia molecular na medicina
Nas últimas décadas, o desenvolvimento da biologia molecular tem impulsionado a medicina, principalmente na identificação de novos alvos terapêuticos e de diagnóstico. Nas células são as proteínas as principais intervenientes ...
Patología del quinto radio. Parte III: Quintus Varus
Se comentan las características de la deformidad y su clasificación en función de la radiología. En relación al tratamiento quirúrgico, en los casos leves se propone una exostectomía asociada a un cerclaje fibroso. En los ...
Iatrogènies medicamentoses
Els processos patològics apareguts com a conseqüència d'un acte mèdic s'agrupen sota el terme 'iatrogènia'. En el cas que siguin deguts a l'acció d'un fàrmac, s'anomenen 'iatrogénies medicamentoses', efectes indesitjables ...
A new disruption vector (pDHO) to obtain heterothallic strains from both Saccharomyces cerevisiae and Saccharomyces pastorianus
Yeasts are responsible for several traits in fermented beverages, including wine and beer, and their genetic manipulation is often necessary to improve the quality of the fermentation product. Improvement of wild-type ...
"Randomización": significado de la aleatoriedad en la investigación clínica
Se comenta el significado de la selección o asignación aleatoria, randomización, en la investigación clínica. Se enumeran las bases teóricas, las implicaciones prácticas de la aleatoriedad, y su influencia en el diseño de ...
Biological properties of extracellular vesicles and their physiological functions
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and ...
