Patologia i Terapèutica Experimental: Recent submissions
Now showing items 61-80 of 1057
Biofunctionalization with a TGF -1 inhibitor peptide in the osseointegration of synthetic bone grafts: an in vivo study in Beagle dogs
Objectives: The aim of this research was to determine the osseointegration of two presentations of biphasic calcium phosphate (BCP) biomaterial¿one untreated and another submitted to biofunctionalization with a TGF- 1 ...
Docencia sobre metodología y ética de la investigación con fármacos basada en el análisis de un incidente crítico
El objetivo docente en un seminario de la asignatura de 'Farmacología' de la licenciatura de Medicina es que los estudiantes desarrollen competencias de comprensión, análisis y evaluación crítica de los aspectos metodológicos ...
Synaptic Zn2+ potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior
Cocaine binds to the dopamine (DA) transporter (DAT) to regulate cocaine reward and seeking behavior. Zinc (Zn2+) also binds to the DAT, but the in vivo relevance of this interaction is unknown. We found that Zn2+ ...
Globular glial tauopathies (GGT): consensus recommendations
Recent studies have highlighted a group of 4-repeat (4R) tauopathies that are characterised neuropathologically by widespread, globular glial inclusions (GGIs). Tau immunohistochemistry reveals 4R immunoreactive globular ...
Incidence and predictive biomarkers of Clostridioides difficile infection in hospitalized patients receiving broad-spectrum antibiotics
Trial enrichment using gut microbiota derived biomarkers by high-risk individuals can improve the feasibility of randomized controlled trials for prevention of Clostridioides difficile infection (CDI). Here, we report in ...
Adenosine A1-A2A receptor-receptor interaction: contribution to guanosine-mediated effects
Guanosine, a guanine-based purine nucleoside, has been described as a neuromodulator that exerts neuroprotective effects in animal and cellular ischemia models. However, guanosine's exact mechanism of action and molecular ...
Mitochondrial modulation with leriglitazone as a potential treatment for Rett syndrome
Background: Rett syndrome is a neuropediatric disease occurring due to mutations in MECP2 and characterized by a regression in the neuronal development following a normal postnatal growth, which results in the loss of ...
On the expanding terminology in the GPCR field: The meaning of receptor mosaics and receptor heteromers
The oligomerization of G protein-coupled receptors (GPCRs) is a fact that deserves further attention as increases both the complexity and diversity of the receptor-mediated signal transduction, thus enriching the cell ...
Systematic protein-protein interaction mapping for clinically relevant human GPCRs
G‐protein‐coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics ...
Cellular redox systems impact the aggregation of CU,Zn Superoxide Dismutase linked to familial Amyotrophic Lateral Sclerosis
Protein misfolding is implicated in neurodegenerative diseases such as ALS, where mutations of superoxide dismutase 1 (SOD1) account for about 20% of the inherited mutations. Human SOD1 (hSOD1) contains four cysteines, ...
PDR-1/hParkin negatively regulates the phagocyosis of apoptotic cell corpses in Caenorhabditis elegans
Apoptotic cell death is an integral part of cell turnover in many tissues, and proper corpse clearance is vital to maintaining tissue homeostasis in all multicellular organisms. Even in tissues with high cellular turnover, ...
Amyotrophic Lateral Sclerosis Is Accompanied by Protein Derangements in the Olfactory Bulb-Tract Axis
Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive muscle paralysis due to the degeneration of upper and lower motor neurons. Recent studies point out an involvement of the non-motor axis ...
Tau phosphorylation in myotilinopathies and desminopathies
Tau expression and tau phosphorylation were examined in muscle biopsies of sporadic inclusion body myositis (sIBM), myotilinopathies and desminopathies compared with controls. A panel of anti-tau antibodies including 3Rtau, ...
Topical Analgesia with Lidocaine Plus Diclofenac Decreases Pain in Benign Anorectal Surgery: Randomized, Double-blind, and Controlled Clinical Trial
Objective: The aim of this study is to evaluate the efficacy and safety of a topical formulation containing lidocaine plus diclofenac (CLIFE1) compared to CLIFE2 (lidocaine), to decrease pain in benign anorectal surgery ...
Toxins Secreted by Bacillus Isolated from Lung Adenocarcinomas Favor the Penetration of Toxic Substances
The aim was to explore the eventual role of bacteria in the induction of lung cancer by smoking habits. Viable bacteria closely related to the genus Bacillus were detected at high frequencies in lung-cancer biopsies. ...
Striatal dopamine D2 adenosine A2A and cannabinoid CB1 receptors balance as a target against non-cognitive symptoms in a mouse model of Alzheimer's disease
Behavioral and psychological symptoms of dementia are almost ubiquitous in Alzheimer's disease (AD) but current therapies are not fully effective and safe. In this study, we aim to evaluate the role played by the interplay ...
Hereditary primary lateral sclerosis and progressive nonfluent aphasia
Objective: to report a kindred with an association between hereditary primary lateral sclerosis (PLS) and progressive nonfluent aphasia. Patients and methods: six members from a kindred with 15 affected individuals spanning ...
Cerebrospinal fluid total prion protein in the spectrum of prion diseases
Cerebrospinal fluid (CSF) total prion protein (t-PrP) is decreased in sporadic Creutzfeldt-Jakob disease (sCJD). However, data on the comparative signatures of t-PrP across the spectrum of prion diseases, longitudinal ...
Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target
The human brain is a target of the aging process like other cell systems of the human body. Specific regions of the human brain exhibit differential vulnerabilities to the aging process. Yet the underlying mechanisms that ...
An intriguing shift occurs in the novel protein phosphatase 1 binding partner, TCTEX1D4: evidence of positive selection in a pika model
T-complex testis expressed protein 1 domain containing 4 (TCTEX1D4) contains the canonical phosphoprotein phosphatase 1 (PPP1) binding motif, composed by the amino acid sequence RVSF. We identified and validated the binding ...
