Patologia i Terapèutica Experimental: Envíos recientes
Mostrando ítems 41-60 de 1057
Oxidative damage compromises energy metabolism in the axonal degeneration mouse model of X-adrenoleukodystrophy
Aims: Chronic metabolic impairment and oxidative stress are associated with the pathogenesis of axonal dysfunction in a growing number of neurodegenerative conditions. To investigate the intertwining of both noxious factors, ...
Swine as an experimental model in dentistry: a proposal of surgical approach
Swine is widely used as an experimental model in several areas of medicine based on its anatomical and physiological similarities to humans. In this report, we describe an external surgical approach on the mandible of the ...
Indole-based perenosins as highly potent HCl transporters and potential anti-cancer agents
Prodigiosin is one of the most potent anion transporters in lipid bilayer membranes reported to date. Inspired by the structure of this natural product, we have recently designed and synthesised a new class of H+/Cl− ...
Methodology for the at-home collection of urine samples for prostate cancer detection
Urine from patients with prostate cancer (PCa) contains gene transcripts that have been used for PCa diagnosis and prognosis. Historically, patient urine samples have been collected after a digital rectal examination of ...
Influencia de los cambios postreperfusión del donante en la evolución del injerto tras el trasplante hepático
Introducción: el incremento de las indicaciones de trasplante hepático ha comportado el alargamiento de las listas de espera. Por este motivo la ampliación en la utilización de los donantes marginales es una prioridad para ...
Prevalence and molecular characterization of methicillin-resistant S. aureus ST398 resistant to tetracycline at a Spanish hospital over 12 years
Methicillin-resistant Staphylococcus aureus (MRSA) ST398, associated with livestock animals, was described in 2003 as a new lineage infecting or colonizing humans. We evaluated the prevalence and molecular characteristics ...
Altered gene transcription linked to astrocytes and oligodendrocytes in frontal cortex in Creutzfeldt-Jakob disease
Targeted expression of genes coding for proteins specific to astrocytes, oligodendrocytes and myelin was performed in frontal cortex area 8 of Creutzfeldt-Jakob disease methionine/methionine and valine/valine (CJD MM1 and ...
Amygdalar CB2 cannabinoid receptor mediates fear extinction deficits promoted by orexin-A/hypocretin-1
Anxiety and stress disorders are often characterized by an inability to extinguish learned fear responses. Orexins/ hypocretins are involved in the modulation of aversive memories, and dysregulation of this system may ...
Mesencephalic dopaminergic neurons express a repertoire of olfactory receptors and respond to odorant-like molecules
Background: the mesencephalic dopaminergic (mDA) cell system is composed of two major groups of projecting cells in the Substantia Nigra (SN) (A9 neurons) and the Ventral Tegmental Area (VTA) (A10 cells). Selective ...
A pathogenic mechanism in Huntington"s disease involves small CAG-repeated RNAs with neurotoxic activity
Huntington's disease (HD) is an autosomal dominantly inherited disorder caused by the expansion of CAG repeats in the Huntingtin (HTT) gene. The abnormally extended polyglutamine in the HTT protein encoded by the CAG repeats ...
New mutants of epsilon toxin from clostridium perfringens with an altered receptor-binding site and cell-type specificity
Epsilon toxin (Etx) from Clostridium perfringens is the third most potent toxin after the botulinum and tetanus toxins. Etx is the main agent of enterotoxemia in ruminants and is produced by Clostridium perfringens toxinotypes ...
GATA2 deficiency and MDS/AML: experimental strategies for disease modelling and future therapeutic prospects
The importance of predisposition to leukaemia in clinical practice is being increasingly recognized. This is emphasized by the establishment of a novel WHO disease category in 2016 called 'myeloid neoplasms with germline ...
Phosphoprotein phosphatase 1 isoforms alpha and gamma respond differently to prodigiosin treatment and present alternative kinase targets in melanoma cells
Reversible protein phosphorylation is a central regulatory mechanism of cell function. Deregulation of the balanced actions of protein kinases and phosphatases has been frequently associated with several pathological ...
Efficacy and safety of plasma exchange with 5% albumin to modify cerebrospinal fluid and plasma amyloid-β concentrations and cognition outcomes in Alzheimer's disease patients: a multicenter, randomized, controlled clinical trial
Background: studies conducted in animal models and humans suggest the presence of a dynamic equilibrium of amyloid-β (Aβ) peptide between cerebrospinal fluid (CSF) and plasma compartments. Objective: to determine whether ...
Differences in Tau Seeding in Newborn and Adult Wild-Type Mice
Alzheimer’s disease (AD) and other tauopathies are common neurodegenerative diseases in older adults; in contrast, abnormal tau deposition in neurons and glial cells occurs only exceptionally in children. Sarkosyl-insoluble ...
Sporadic Creutzfeldt-Jakob disease with glial PrPRes nuclear and perinuclear immunoreactivity
Proteinase K-resistant prion protein (PrPRes ) nuclear and perinuclear immunoreactivity in oligodendrocytes of the frontal cortex is found in one case of otherwise typical sporadic Creutzfeldt-Jakob disease (sCJD) type ...
Characterization of nontypable haemophilus influenzae isolates recovered from adult patients with underlying chronic lung disease reveals genotypic and phenotypic traits associated with persistent infection
Trobareu correccions del document a: http://dx.doi.org/10.1371/journal.pone.0107686
Altered machinery of protein synthesis in Alzheimer's: from the nucleolus to the ribosome
Ribosomes and protein synthesis have been reported to be altered in the cerebral cortex at advanced stages of Alzheimer's disease (AD). Modifications in the hippocampus with disease progression have not been assessed. ...
Studies with the Golgi method in central gangliogliomas and dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease)
The rapid Golgi method, combined with current optical and electronmicroscopica1 techniques, was used in three central gangliogliomas and in one dysplastic gangliocytoma of the cerebellum to study the morphology of ganglionic ...
Biofunctionalization with a TGF -1 inhibitor peptide in the osseointegration of synthetic bone grafts: an in vivo study in Beagle dogs
Objectives: The aim of this research was to determine the osseointegration of two presentations of biphasic calcium phosphate (BCP) biomaterial¿one untreated and another submitted to biofunctionalization with a TGF- 1 ...
