Patologia i Terapèutica Experimental: Recent submissions
Now showing items 1-20 of 1057
Future prospects for Antimicrobial peptide development: peptidomimetics and antimicrobial combinations
Antimicrobial resistance is widely recognized as one of the major challenges of public health worldwide, as infections by multidrug-resistant (MDR) bacteria have reached worrisome levels. Three levels of antibiotic resistance ...
Dense core vesicle markers in CSF and cortical tissues of patients with Alzheimer's disease
Background: New fluid biomarkers for Alzheimer's disease (AD) that reveal synaptic and neural network dysfunctions are needed for clinical practice and therapeutic trial design. Dense core vesicle (DCV) cargos are promising ...
Variability vs. phenotype: Multimodal analysis of Dravet syndrome brain organoids powered by deep learning
Dravet syndrome (DS) is a developmental epileptic encephalopathy (DEE) driven by pathogenic variants in the SCN1A gene. Brain organoids (BOs) have emerged as reliable models for neurodevelopmental genetic disorders, ...
Identification of the atypical antipsychotic Asenapine as a direct survivin inhibitor with anticancer properties and sensitizing effects to conventional therapies
Therapy resistance in human cancers is a major limitation in Clinical Oncology. In this regard, overexpression of anti-apoptotic proteins, such as survivin, has been described in several tumors, contributing to this clinical ...
Photoswitching endogenous glutamate receptors in neural ensembles and single synapses in vivo
Purpose: To interrogate animal physiology in vivo, there is a lack of non-genetic methods to control the activity of endogenous proteins with pharmacological and spatiotemporal precision. To address this need, we recently ...
CRISPR-engineered human GATA2 deficiency model uncovers mitotic dysfunction and premature aging in HSPCs, impairing hematopoietic fitness
GATA2 deficiency is a monogenic transcriptopathy disorder characterized by bone marrow failure (BMF), immunodeficiency, and a high risk of developing myelodysplastic neoplasms (MDS) and acute myeloid leukemia (AML). Although ...
Intraoperative brain mapping in multilingual patients: what do we know and where are we going?
In this review, we evaluate the knowledge gained so far about the neural bases of multilingual language processing obtained mainly through imaging and electrical stimulation mapping (ESM). We attempt to answer some key ...
Altered resting-state functional connectivity in individuals at risk for Alzheimer’s disease: a longitudinal study
Background: Resting-state functional connectivity magnetic resonance imaging (rs-fMRI) is a sensitive tool for detecting early brain changes associated with Alzheimer's disease, even in its preclinical stages. Amnestic ...
Long-lasting behavioral, molecular and functional connectivity alterations after chronic THC exposure during adolescence in mice
Heavy and daily use of cannabis with high contents of Delta 9-tetrahydrocannabinol (THC) during adolescence is associated with an increased risk of developing psychotic disorders later in life. Here, we treated mice with ...
Circulating endothelial progenitor cell colony-forming capacity in healthy subjects: how does an endothelial colony look like?
We read with great interest the recent report in the American Journal of Cardiology by Hoetzer et al.1 The investigators addressed the question of whether in healthy, middle-aged subjects circulating endothelial progenitor ...
Variations in the course and diameter of the suprascapular nerve: Anatomical study
Suprascapular neuropathy is an important factor contributing to shoulder pain. Given the prevalence of nerve injury and nerve block in the suprascapular notch region, as well as the frequency of arthroscopic procedures on ...
Compartir ideas. La Universidad va al Instituto: un proyecto de aprendizaje- servicio transversal de la Universidad de Barcelona
Compartir ideas. La universidad va al instituto es un proyecto de aprendizaje servicio transversal de la Universidad de Barcelona. Este representa una propuesta de aprendizaje servicio que bajo una estructura común permite ...
The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity
The ascending midbrain 5-HT neurons to the forebrain may be dysregulated in depression and have a reduced trophic support. With in situ proximity ligation assay (PLA) and supported by coimmunoprecipitation and colocation ...
Low-dose statin treatment increases prostate cancer aggressiveness
Prostate cancer is diagnosed late in life, when co-morbidities are frequent. Among them, hypertension, hypercholesterolemia, diabetes or metabolic syndrome exhibit an elevated incidence. In turn, prostate cancer patients ...
Molecular Interactions of Prodiginines with the BH3 Domain of Anti-Apoptotic Bcl-2 Family Members.
Prodigiosin and obatoclax, members of the prodiginines family, are small molecules with anti-cancer properties that are currently under preclinical and clinical trials. The molecular target(s) of these agents, however, is ...
Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease
Although exact causes of Parkinson disease (PD) remain enigmatic, mitochondrial dysfunction is increasingly appreciated as a key determinant of dopaminergic neuron susceptibility in both familial and sporadic PD. Two genes ...
Study of the protein complex, pore diameter, and pore-forming activity of the Borrelia burgdorferi P13 porin
P13 is one of the major outer membrane proteins of Borrelia burgdorferi. Previous studies described P13 as a porin. In the present study some structure and function aspects of P13 were studied. P13 showed according to lipid ...
Anterior transtemporal endoscopic selective amygdalohippocampectomy: a virtual and cadaveric feasibility study
Purpose: Selective amygdalohippocampectomy (SelAH) is one of the most common surgical treatments for mesial temporal sclerosis. Microsurgical approaches are associated with the risk of cognitive and visual deficits due to ...
Homing of peripherally injected bone marrow cells in rat after experimental myocardial injury
Background and objectives: significant progress has been achieved during the past 10 years in cell transplantation and recent research has focused on the possibility of improving ventricular function after myocardial ...
Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells
Generation of human induced pluripotent stem cells (hiPSCs) by the expression of specific transcription factors depends on successful epigenetic reprogramming to a pluripotent state. Although hiPSCs and human embryonic ...
