Patologia i Terapèutica Experimental: Recent submissions
Now showing items 81-100 of 1057
The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland
The mammary gland is a very dynamic organ that undergoes continuous remodeling. The critical regulators of this process are not fully understood. Here we identify the microRNA cluster miR-424(322)/503 as an important ...
Pulmonary delivery of Interleukin 7 provides efficient and safe delivery to the aging immune system
Age-associated atrophy of the thymus with coincident reduction in thymopoeisis, decline in thymic output, and subsequent immune dysfunction has been reversed by the use of interleukin-7 (IL-7). In the earlier studies and ...
Técnicas de diafanización: estudio comparativo
Las técnicas de diafanización dental, han sido frecuentemente empleadas para evaluar diferentes aspectos anatómicos y endodóncicos, son muy variables y se utilizan principalmente con objetivos docentes. El propósito de ...
Aspectos ultrastructurais do fibroblasto do ligamento periodontal
Os autores descrevem as principais alterações ultrastruturais encontradas ao nível dos fibroblastos do ligamento periodontal, a partir de colheitas efectuadas no desmodonto. Os cortes ultrastruturais evidenciam as diferenças ...
Compartments of the crural fascia: clinically relevant ultrasound, anatomical and histological findings
Purpose: Compartment syndrome is a surgical emergency that can occur in any part of the body and can cause cell necrosis when maintained over time. The resulting defects can affect the nerves, muscle cells, bone tissue, ...
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats
New granule cells are born throughout life in the dentate gyrus of the hippocampal formation. Given the fundamental role of the hippocampus in processes underlying certain forms of learning and memory, it has been speculated ...
Delayed diagnosis of tuberculosis in persons living with HIV in Eastern Europe: associated factors and effect on mortality-a multicentre prospective cohort study
Background: Early diagnosis of tuberculosis (TB) is important to reduce transmission, morbidity and mortality in people living with HIV (PLWH). Methods: PLWH with a diagnosis of TB were enrolled from HIV and TB clinics in ...
El cuestionario-historia-clínica informatizado: entrada, ensayo de viabilidad y estructuración de la información en A.E.D.M.I.
Se presenta un cuestionario-historia clínica informatizado para la creación de dos bases de datos, una de hechos clínicos y otra de conocimentos médicos, adaptadas al Programa AEDMI. Facilita además automática e inmediatamente ...
Manipulating TLR signaling increases the anti-tumor T Cell response induced by viral cancer therapies
The immune response plays a key role in enhancing the therapeutic activity of oncolytic virotherapies. However, to date, investigators have relied on inherent interactions between the virus and the immune system, often ...
Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis
Murine inflammatory caspase-11 has an important role in intestinal epithelial inflammation and barrier function. Activation of the non-canonical inflammasome, mediated by caspase-11, serves as a regulatory pathway for the ...
Implementing reflective multicriteria decision analysis (MCDA) to assess orphan drugs value in the Catalan Health Service (CatSalut)
Background: orphan medicines show some characteristics that hinder the evaluation of their clinical added value. The often low level of evidence available for orphan drugs, together with a high budget impact and an incremental ...
SPARC triggers a cell-autonomous program of synapse elimination
Elimination of the excess synaptic contacts established in the early stages of neuronal development is required to refine the function of neuronal circuits. Here we investigate whether secreted protein acidic and rich in ...
Homing of peripherally injected bone marrow cells in rat after experimental myocardial injury
Background and objectives: significant progress has been achieved during the past 10 years in cell transplantation and recent research has focused on the possibility of improving ventricular function after myocardial ...
Acupuncture and radioactive pathways of hypodermically injected technetium-99m
To the editor: In our opinion, some of the interpretations of Scott and Vernejoul and associates are not supported by the data contained in a recently published study by our group.
Regulation of exocytotic fusion by cell inflation
We have inflated patch-clamped mast cells by 3.8 +/- 1.6 times their volume by applying a hydrostatic pressure of 5-15 cm H2O to the interior of the patch pipette. Inflation did not cause changes in the cell membrane ...
Relation between seminal quality and oxidative balance in sperm cells
Objectives: infertility is a clinical disorder affecting approximately 15% of reproductive-aged couples worldwide. Recently, the influence of oxidative stress (OS) in decreased semen quality has been discussed. OS corresponds ...
Use of venous thromboprophylaxis and adherence to guideline recommendations: a cross-sectional study.
BACKGROUND: Consensus Conferences and Guidelines for deep vein thrombosis prophylaxis have been published, which recommend the use of prophylactic heparins in patients with risk of venous thromboembolism (VTE). The aim of ...
Anatomical study of minimally invasive lateral release techniques for hallux valgus treatment
Background: Lateral release (LR) for the treatment of hallux valgus is a routinely performed technique, either by means of open or minimally invasive (MI) surgery. Despite this, there is no available evidence of the efficacy ...
Resultados de la estadificación clínica ganglionar mediastínica del cáncer pulmonar quirúrgico: datos de la cohorte prospectiva nacional del Grupo Español de Cirugía Torácica Videoasistida
Introducción: El objetivo del estudio es valorar el rendimiento diagnóstico de la tomografía computarizada (TC) y la tomografía por emisión de positrones (PET) en la estadificación clínica mediastínica del cáncer pulmonar ...
Somatic coding mutations in human induced pluripotent stem cells
Defined transcription factors can induce epigenetic reprogramming of adult mammalian cells into induced pluripotent stem cells. Although DNA factors are integrated during some reprogramming methods, it is unknown whether ...
