Patologia i Terapèutica Experimental: Recent submissions
Now showing items 41-60 of 1057
Novel use of cranial epidural space in rabbits as an animal model to investigate bone volume augmentation potent
Background: the success of bone augmentation to a major degree depends on the biomechanics and biological conditions of the surrounding tissues. Therefore, an animal model is needed providing anatomical sites with similar ...
Identification of dual mTORC1 and mTORC2 inhibitors in melanoma cells: Prodigiosin vs.obatoclax
The PI3K/AKT/mTOR signaling pathway regulates cell proliferation, survival and angiogenesis.The mammalian target of rapamycin (mTOR)is a protein kinase ubiquitously expressed within cells that regulates cell growth and ...
'Salud+Informática'
La revista NOVATICA ha tenido a bien reunir en este número monográfico un conjunto de trabajos que en su día formaron parte de una Jornada científica celebrada en el Hospital de Bellvitge 'Príncipes de España' sobre SOPORTE ...
Educational sessions in pharmacovigilance: What do the doctors think?
Background: The aim of this study was to determine physicians"opinion regarding pharmacovigilance feedback sessions. A survey was conducted in a teaching hospital, and the physicians who attended the sessions were invited ...
Oral pathogens in duwl's: risk of infection and strategies for their control
Water lines are an important source of potentíal contamination. Every dental unit is equipped with small-bore flexible plastic tubing to bring water to different hand pieces, such as the air/water syringe, the ultrasonic ...
G Protein-Coupled Receptor heterodimerization in the brain
G protein-coupled receptors (GPCRs) play critical roles in cellular processes and signaling and have been shown to form heteromers with diverge biochemical and/or pharmacological activities that are different from those ...
Histomorphometric analysis of osseointegrated grade V titanium mini transitional implants inEdentulous mandible by backscattered scanning electron microscopy (BS-SEM)
The purpose of this study is to assess the use of grade V titanium mini transitional implants(MTIs) immediately loaded by a temporary overdenture. For this, a histomorphometric analysisof the bone area fraction occupancy ...
Prognostic value of replication errors on chromosomes 2p and 3p in non-small-cell lung cancer
As chromosomes 2p and 3p are frequent targets for genomic instability in lung cancer, we have addressed whether alterations of simple (CA)n DNA repeats occur in non-small-cell lung cancer (NSCLC) at early stages. We have ...
Functional approach using intraoperative brain mapping and neurophysiological monitoring for the surgical treatment of brain metastases in the central region
Objective: Brain metastases are the most frequent intracranial malignant tumor in adults. Surgical intervention for metastases in eloquent areas remains controversial and challenging. Even when metastases are not infiltrating ...
Transforming growth factor -α expression in rat experimental hepatocarcinogenesis
Growth factors in general and transforming growth factor-alpha in particular have been related to cell proliferation and cell differentiation. This study was designed to clarify the distribution pattem of TGF-alpha in ...
Acinetobacter sp: importància com a patogen nosocomial en l'actualitat
El gènere Acinetobacter està format per bacils gramnegatius immòbils àmpliament distribuïts en la natura. Des de la seva descripció, els membres d'aquest gènere han patit nombrosos canvis taxonòmics, en part a causa de ...
Proteins influencing foam formation in wine and beer: the role of yeast
This review focuses on the role of proteins in the production and maintenance of foam in both sparkling wines and beer. The quality of the foam in beer but especially in sparkling wines depends, among other factors, on the ...
Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells
Generation of human induced pluripotent stem cells (hiPSCs) by the expression of specific transcription factors depends on successful epigenetic reprogramming to a pluripotent state. Although hiPSCs and human embryonic ...
Cord blood-derived neuronal cells by ectopic expression of SOX2 and c-MYC
The finding that certain somatic cells can be directly converted into cells of other lineages by the delivery of specific sets of transcrip- tion factors paves the way to novel therapeutic applications. Here we show that ...
Kinematic and Kinetic Adaptations to Step Cadence ModulationDuringWalking in Healthy Adults
Walking cadence is commonly adjusted in sport and rehabilitation, yet itseffects on spatiotemporal gait parameters and regional plantar pressure distribution undercontrolled speed conditions remain incompletely characterized. ...
Regulatory framework for advanced therapy medicinal products in Europe and United States
Advanced therapy medicinal products (ATMPs) are a fast-growing field of innovative therapies. The European Union (EU) and the United States (US) are fostering their development. For both regions, ATMPs fall under the ...
Subcortical anatomy as an anatomical and functional landmark in insulo-opercular gliomas: implications for surgical approach to the insular region
Object: Little attention has been given to the functional challenges of the insular approach to the resection of gliomas, despite the potential damage of essential neural networks that underlie the insula. The object of ...
Determination of the spatiotemporal dependence of Pseudomonas aeruginosa biofilm viability after treatment with NLC-colistin
The emergence of colistin-resistant Pseudomonas aeruginosa in cystic fibrosis (CF) patients, particularly after long-term inhalation treatments, has been recently reported. Nanoencapsulation may enable preparations to ...
Transautocrine signaling by membrane neuregulins requires cell surface targeting, which is controlled by multiple domains
The neuregulins (NRGs) play important roles in animal development and homeostasis, and their deregulation has been linked to diseases such as cancer and schizophrenia. The NRGs belong to the epidermal growth factor (EGF) ...
Microtubule depolymerization contributes to spontaneous neurotransmitter release in vitro
Microtubules are key to multiple neuronal functions involving the transport of organelles, however, their relationship to neurotransmitter release is still unresolved. Here, we show that microtubules present in the presynaptic ...
