Farmacologia, Toxicologia i Química Terapèutica: Recent submissions
Now showing items 61-80 of 675
Moths behaving like butterflies. Evolutionary loss of long range attractant pheromones in Castniid Moths: A Paysandisia archon model
Background: In the course of evolution butterflies and moths developed two different reproductive behaviors. Whereas butterflies rely on visual stimuli for mate location, moths use the"female calling plus male seduction" ...
Pd0-Catalyzed Intramoleculara-Arylation of Sulfones: Domino Reactions in the Synthesis of Functionalized Tetrahydroisoquinolines
A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd(0)-catalyzed intramolecular α-arylation of sulfones is reported. The combination of this Pd-catalyzed reaction with intermolecular Michael and ...
Facile Access to Solifenacin Impurity K: One-Step Synthesis and an HPLC-MS Method for Its Determination.
<span style="color:rgb( 34 , 34 , 34 )">Solifenacin (SFC) is a potent muscarinic antagonist that effectively reduces bladder muscle contraction, thereby alleviating symptoms such as frequency of micturition and urgency. ...
Bempedoic Acid Restores Liver H2S Production in a Female Sprague-Dawley Rat Dietary Model of Non-Alcoholic Fatty Liver
We previously demonstrated that treatment with BemA (bempedoic acid), an inhibitor of ATP citrate lyase, significantly reduces fatty liver in a model of liver steatosis (HFHFr-female Sprague-Dawley rat fed a high-fat ...
Modulating the Biological Function of Protein by Tailoring the Adsorption Orientation on Nanoparticles
Protein orientation in nanoparticle-protein conjugates plays a crucial role in binding to cell receptors and ultimately, defines their targeting efficiency. Therefore, understanding fundamental aspects of the role of protein ...
A rhein-huprine hybrid protects erythrocyte membrane integrity against Alzheimer's disease related Abeta(1-42) peptide
Alzheimer's disease remains largely unknown, and currently there is no complete cure for the disease. New synthetic approaches have been developed to create multi-target agents, such as RHE-HUP, a rhein-huprine hybrid which ...
CH....X (X = O, N, p) interactions in benzyl carbamate
The crystal packing and interaction energy of benzyl carbamate, C(8)H(9)NO(2), have been analysed in detail by the PIXEL method. Benzyl carbamate forms layers of hydrogen-bonded molecules, with the layers connected by ...
Informe final del tutor de pràctiques externes a empresa (curs acadèmic 2017-2018)
Aquest document és l'informe del tutor d'empresa de l'any acadèmic 2017-2018 necessaria per a l'avaluació de l'assignatura optativa pràctiques en empreses del Grau de Farmàcia de la Facultat de Farmàcia i Ciències de ...
Heterocycle-Based Multicomponent Reactions in Drug Discovery: From Hit Finding to Rational Design
In the context of the structural complexity necessary for a molecule to selectively display a therapeutical action and the requirements for suitable pharmacokinetics, a robust synthetic approach is essential. Typically, ...
Understanding Epigenetics in the Neurodegeneration of Alzheimer's Disease: SAMP8 Mouse Model
Epigenetics is emerging as the missing link among genetic inheritance, environmental influences, and body and brain health status. In the brain, specific changes in nucleic acids or their associated proteins in neurons and ...
Strategies for the synthesis of enantiopure compounds focused on organocatalysis
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32393
Preclinical Evaluation of an Imidazole-Linked Heterocycle for Alzheimer's Disease
Humanity is facing a vast prevalence of neurodegenerative diseases, with Alzheimer's disease (AD) being the most dominant, without efficacious drugs, and with only a few therapeutic targets identified. In this scenario, ...
Studies on the Regioselectivity of the Cyclization of Tryptophanol-Derived Oxazolopiperidone Lactams
Cyclization of the lactam carbonyl on the indole ring in tryptophanol-derived oxazolopiperidone lactams 2 and 6, under the classical POCl3-promoted Bischler-Napieralski conditions and under neutral conditions via the ...
PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders
Research in recent years on peroxisome proliferator-activated receptor (PPAR)β/δ indicates that it plays a key role in the maintenance of energy homeostasis, both at the cellular level and within the organism as a whole. ...
Ús de la WebQuest com a eina per l'adquisició de competències transversals del Grau de Farmàcia
Podeu consultar la Setena trobada de professorat de Ciències de la Salut completa a: http://hdl.handle.net/2445/43352
Synthesis of the ABC ring of calyciphylline A-type alkaloids by a stereocontrolled aldol cyclization: Formal synthesis of (±)-Himalensine A
A synthetic approach to a functionalized ABC-tricyclic framework of calyciphilline A-type alkaloids, a building block toward this class of alkaloids, is reported. The key synthetic steps involve a radical cyclization to ...
Palladium-catalyzed intramolecular carbene insertion into C(sp3)-H bonds
A palladium‐catalyzed carbene insertion into C(sp3)−H bonds leading to pyrrolidines was developed. The coupling reaction can be catalyzed by both Pd0 and PdII, is regioselective, and shows a broad functional group tolerance. ...
“Synthetic Map”: A Graphic Organizer Inspired by Artificial Neural Network Paradigms for Learning Organic Synthesis.
Organic Chemistry is widely recognized as a challenging subject, with the design of syntheses and retrosyntheses identified as particularly difficult tasks. Inspired by the success of artificial neural networks in machine ...
Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice
Combination of the scaffolds of the cholinesterase inhibitor huprine Y and the antioxidant capsaicin results in compounds with nanomolar potencies toward human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) ...
The Cream of the Crop of the Medicinal Chemistry Section of Molecules 2019
The MDPI journal Molecules is organized into 25 sections that cover many different areas of the broad field of chemistry. Among them, the Medicinal Chemistry section is one of the most classical. The overarching aim of ...
