Universitat de Barcelona
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Política d’accés obert a la UB
Publicacions en accés obert derivades de l'activitat investigadora del professorat de la Universitat de Barcelona.
Attempts to synthesize the natural product macrolide polyketide (–)-callyspongiolide have drawn great interest</p><p>because of its potent cytotoxic activity. Its total synthesis has proven to be difficult, however, due ...
Solvated supramolecular hydrogels present unique challenges in nanoscale morphological characterization because of their fragile</p><p>fibrous nature and low concentration of the solid component. In this study, imidazolium-based ...
The single-crystal structures of Oxyma-T, the recent member of the Oxyma racemization-suppressor family for peptide synthesis, have been synthesized and structurally characterized by single-crystal X-ray diffraction (SCXRD). ...
Four new crystal structures of OXYMA-B in its anionic form have been synthesized and structurally characterized via single-crystal X-ray diffraction. The new salts incorporate protonated amine-based cations including ...
New leukotriene B4 (LTB4) antagonists have been synthesized that can be considered as potential anti-inflammatory drugs. Structures containing the dioxygenated nucleus of 1,4-benzodioxine constitute a potential group of ...
A novel and efficient method for synthesizing a-aminophosphonates was developed through a Kabachnik–Fields multicomponent reaction using 6-aminocoumarin or 6-aminobenzodioxane, benzaldehyde, triethylphosphite, and a catalytic ...
Introduction: Aerobic and resistance training can effectively improve clinicalmanagement in people with type 2 diabetes (T2D). Low vitamin D (VitD) levels areassociated with T2D risk and metabolic disturbances, and may ...
Drug combination and repurposing are potential therapeutic strategies for the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we have demonstrated that, in rats, both pemafibrate and ...
In a randomized, cross-over feeding trial involving 10 men with polygenic hypercholesterolemia, a control, Mediterranean-type cholesterol-lowering diet, and a diet of similar composition in which walnuts replaced approximately ...
Sex differences may play a role in the etiopathogenesis and severity of metabolic dysfunction-associated steatotic liver disease (MASLD), a disorder characterized by excessive fat accumulation associated with increased ...
The increasing number of new psychoactive substances (NPS) entering the illicit drug market, especially synthetic cathinones, as well as the risk of cardiovascular complications, is intensifying the need to quickly assess ...
The synthesis of the Lycopodium alkaloid ( )-cermizine B (1), which establishes its absolute configuration, is achieved by combining asymmetric organocatalysis and an uninterrupted eight-step reaction sequence, followed ...
Aquest article és el primer que es va obtenir en el context de la tesi doctoral. Es va publicar a finals de 2012 - principis de 2013. Es descriu</p><p>el primer dels resultats que es varen obtenir, i que va ser la clau per ...
The synthesis of tetrahydrospiro[pyrazole-4,5'-pyrazolo[3,4-b]pyridine] derivativesusing Mg/Fe-LDH as a heterogeneous catalyst was reported. This methodology usedfor the condensation of pyrazolones with aldehydes in a basic ...
TheP2X7receptorisanATP-gated ion channel that activates inflammatory pathways involved in diseases such as cancer, atherosclerosis, and neurodegeneration. However, despite the potential benefits of blocking overactive ...
The role of peroxisome proliferator-activated receptor (PPAR)β/δ in hepatic fibrosis remains a subject of debate. Here, we examined the effects of a PPARβ/δ agonist on the pathogenesis of liver fibrosis and the activation ...
Environmental factors, such as exposure to neurotoxicants and diet, play a critical role in shaping cognitive</p><p>function, particularly in genetically susceptible individuals. Chlorpyrifos (CPF), an organophosphate ...
The [5–6–7] azatricyclic ABC core, found in several Daphniphyllum alkaloids, has been synthesized through a novel route involving ring expansion of a perhydroindolone to afford the AC ring system and a radical B ring closure ...
Abstract Population pharmacokinetic (popPK) models are an essential tool when implementing therapeutic drug monitoring (TDM) and to overcome dosing challenges in neonates in clinical practice. Since vancomycin, gentamicin, ...
Background Neuroinflammation is widely recognized as a significant hallmark of Alzheimer's disease (AD). To combat neuroinflammation, the inhibition of the soluble epoxide hydrolase (sEH) enzyme has been demonstrated ...
