Universitat de Barcelona
2019-01-30T13:51:43Z
2019-01-30T13:51:43Z
2016-04-15
2019-01-30T13:51:43Z
A palladium‐catalyzed carbene insertion into C(sp3)−H bonds leading to pyrrolidines was developed. The coupling reaction can be catalyzed by both Pd0 and PdII, is regioselective, and shows a broad functional group tolerance. This reaction is the first example of palladium‐catalyzed C(sp3)−C(sp3) bond assembly starting from diazocarbonyl compounds. DFT calculations revealed that this direct C(sp3)−H bond functionalization reaction involves an unprecedented concerted metalation-deprotonation step.
Article
Accepted version
English
Pal·ladi (Element químic); Catàlisi; Síntesi orgànica; Complexitat computacional; Química organometàl·lica; Palladium; Catalysis; Organic synthesis; Computational complexity; Organometallic chemistry
Wiley-VCH
Versió postprint del document publicat a: https://doi.org/10.1002/anie.201602020
Angewandte Chemie-International Edition, 2016, vol. 55, num. 22, p. 6467-6470
https://doi.org/10.1002/anie.201602020
(c) Wiley-VCH, 2016
