Farmacologia, Toxicologia i Química Terapèutica: Recent submissions
Now showing items 261-280 of 675
Recent advances in lamellarin alkaloids: isolation, synthesis and activity
Lamellarins are a large family of marine alkaloids with potential anticancer activity that have been isolated from diverse marine organisms, mainly ascidians and sponges. All lamellarins feature a 3,4-diarylpyrrole system. ...
Species-specific developmental toxicity in rats and rabbits: generation of a reference compound list for development of alternative testing approaches
For regulatory information requirements, developmental toxicity testing is often conducted in two mammalian species. In order to provide a set of reference compounds that could be used to explore alternative approaches to ...
mTOR is a Key Protein Involved in the Metabolic Effects of Simple Sugars
One of the most important threats to global human health is the increasing incidences of metabolic pathologies (including obesity, type 2 diabetes and non-alcoholic fatty liver disease), which is paralleled by increasing ...
Facile synthesis of azocino[4,3-b]indoles by ring-closing metathesis
The azocino[4,3-b]indole system, tricyclic substructure of the indole alkaloids apparicine and ervaticine, is efficiently assembled by ring-closing metathesis of 2-allyl-3-(allylaminomethyl)indoles. The metathesis sites ...
“Synthetic Map”: A Graphic Organizer Inspired by Artificial Neural Network Paradigms for Learning Organic Synthesis.
Organic Chemistry is widely recognized as a challenging subject, with the design of syntheses and retrosyntheses identified as particularly difficult tasks. Inspired by the success of artificial neural networks in machine ...
Inflammation and metabolic dysregulation in diabetic cardiomyopathy
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/67430
Inhibition of 11β-HSD1 Ameliorates Cognition and Molecular Detrimental Changes after Chronic Mild Stress in SAMP8 Mice
Impaired glucocorticoid (GC) signaling is a significant factor in aging, stress, and neurodegenerative diseases such as Alzheimer's disease. Therefore, the study of GC-mediated stress responses to chronic moderately stressful ...
Synthesis of phenylalaninol-derived oxazolopyrrolidone lactams and evaluation as NMDA receptor antagonists
N-Methyl-D-aspartate (NMDA) receptor antagonists are known to rescue neuronal cell death caused by excessive activation of glutamate receptors. This phenomenon, known as excitotoxicity, is implicated in the pathogenesis ...
Palladium-catalyzed intramolecular carbene insertion into C(sp3)-H bonds
A palladium‐catalyzed carbene insertion into C(sp3)−H bonds leading to pyrrolidines was developed. The coupling reaction can be catalyzed by both Pd0 and PdII, is regioselective, and shows a broad functional group tolerance. ...
Ús de la WebQuest com a eina per l'adquisició de competències transversals del Grau de Farmàcia
Podeu consultar la Setena trobada de professorat de Ciències de la Salut completa a: http://hdl.handle.net/2445/43352
Role of JNK in neurodegenerative diseases
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32393
Interaction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases
The prion protein (PrP) binds to various molecular partners, but little is known about their potential impact on the pathogenesis of prion diseases. Here, we show that PrP can interact in vitro with acetylcholinesterase ...
La ingesta materna de fructosa líquida acentúa la dislipemia que origina el consumo de fructosa en la descendencia de hembra adulta
El consumo de bebidas edulcoradas ricas en fructosa ha aumentado de forma considerable en las últimas décadas, de forma paralela a la mayor incidencia de enfermedades tales como la diabetes, la obesidad y las enfermedades ...
Peroxisome Proliferator-Activated Receptor β/δ (PPAR β/δ) as a Potential Therapeutic Target for Dyslipidemia
Dyslipidemia is a powerful predictor of cardiovascular disease in patients at high risk (Turner et al., 1998), such as type 2 diabetic patients. Lowering of LDL-C is the prime target for treatment (2002), but even with ...
Liposomal formulations for waterproofing mucosal membranes
Liposome formulations consisting of lipids contained in the stratum corneum have been recently demonstrated to</p><p>decrease the permeability of mucosae. The permeability barrier of the mucosa is dependent on the presence ...
A bicyclic α-iminophosphonate improves cognitive decline in 5xFAD murine model of neurodegeneration
I2 receptors (I2-IR) are widely distributed in the central nervous system. I2-IR ligands are associated with a neuroprotective effect but, as I2-IR structure remains unknown, the discovery of better and more selective ...
Chemical Probes for Blocking of Influenza A M2 Wild-type and S31N Channels
We report on using the synthetic aminoadamantane-CH2-aryl derivatives 1-6 as sensitive probes for blocking M2 S31N and influenza A virus (IAV) M2 wild-type (WT) channels as well as virus replication in cell culture. The ...
Developmental exposure to MDMA (ecstasy) in zebrafish embryos reproduces the neurotoxicity adverse outcome 'lower motor activity' described in humans
The recreational use of MDMA (ecstasy) by pregnant women is associated with impaired neuromotor function in infants, but the Adverse Outcome Pathway behind this effect is not clear yet. We present for the first time the ...
Effects of MDPV on dopamine transporter regulation in male rats. Comparison with cocaine.
RATIONALE: MDPV (3,4-methylenedioxypyrovalerone) is a synthetic cathinone present in bath salts. It is a powerful psychostimulant and blocker of the dopamine transporter (DAT), like cocaine. It is known that acute exposure ...
