Farmacologia, Toxicologia i Química Terapèutica: Envíos recientes
Mostrando ítems 241-260 de 675
Synthesis, Characterization and HPLC Analysis of the (1 S,2 S,5 R)-Diastereomer and the Enantiomer of the Clinical Candidate AR-15512
Abstract: AR-15512 (formerly known as AVX-012 and WS-12) is a TRPM8 receptor agonist currently in phase 2b clinical trials for the treatment of dry eye. This bioactive compound with menthol-like cooling activity has three ...
Insight into the binding of DFG-out allosteric inhibitors to B-Raf Kinase using molecular dynamics and free energy calculations
B-Raf mutations are identified in 40-50% of patients with melanoma and among them, the substitution of valine for glutamic acid at position 600 (V600EB-Raf) is the most frequent. Treatment of these patients with B-Raf ...
PEGylated PLGA nanospheres optimized by design of experiments for ocular administration of dexibuprofen in vitro, ex vivo and in vivo characterization
Dexibuprofen-loaded PEGylated PLGA nanospheres have been developed to improve the biopharmaceuti-cal profile of the anti-inflammatory drug for ocular administration. Dexibuprofen is the active enantiomerof ibuprofen and ...
Comparison of Migration Disturbance Potency of Epigallocatechin Gallate (EGCG) Synthetic Analogs and EGCG PEGylated PLGA Nanoparticles in Rat Neurospheres
Epigallocatechin gallate (EGCG), the main catechin of green tea, is described to have potential health benefits in several fields like oncology, neurology or cardiology. Currently, it is also under pre-clinical investigation ...
"Learning by doing" prácticas en empresa y otras actividades de los estudiantes de farmacia de la Universidad de Barcelona
Introducción: A principios del año 2012 se puso en marcha la asignatura Prácticas en Empresas en la Facultad de Farmacia de Barcelona, a partir de la iniciativa impulsada por el Decanato. La asignatura es optativa y ...
Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas
Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is ...
Internacionalización en el Grado de Farmacia de la Universidad de Barcelona. Análisis de los datos obtenidos en los programas de internacionalización en el Grado de Farmacia
[spa] Los estudiantes del grado de Farmacia demandan que existan más posibilidades para realizar los créditos correspondientes a las prácticas en el extranjero. La Facultad ha realizado esfuerzos en diferentes sentidos ...
Immunomodulatory role of probiotics in early life
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/120717
Magnetic nanoparticles: From diagnosis to therapy
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/128014
Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer's Disease
The inhibition of the enzyme soluble epoxide hydrolase (sEH) has demonstrated clinical therapeutic effects in several peripheral inflammatory-related diseases, with three compounds in clinical trials. However, the role of ...
Memantine loaded PEGylated biodegradable nanoparticles for the treatment of glaucoma
Glaucoma is a multifactorial neurodegenerative disease associated with retinal ganglion cells (RGC) loss. Increasing reports of similarities in glaucoma and other neurodegenerative conditions have led to speculation that ...
Primer "speed-networking" a la Facultat de Farmàcia de la Universitat de Barcelona
Podeu consultar la Vuitena trobada de professorat de Ciències de la Salut completa a: http://hdl.handle.net/2445/66524
Dexibuprofen biodegradable nanoparticles: one step closer towards a better ocular interaction study
Ocular inflammation is one of the most prevalent diseases in ophthalmology, which can affect various parts of the eye or the surrounding tissues. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, are commonly ...
The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax
Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins. In the study herein, the pro-apoptotic effect of fluorizoline was assessed in 34 primary samples from patients with ...
Seeking new polymorphs in pharmaceutical cocrystals: focus on furosemide–ethenzamide
Polymorphism remains a critical challenge in the pharmaceutical industry due to its profound impact on the physicochemical and biopharmaceutical properties of active pharmaceutical ingredients (APIs). While pharmaceutical ...
Suspended Planar-Array Chips for Molecular Multiplexing at the Microscale
Suspended planar-array (SPA) chips embody millions of individual miniaturized arrays to work in extremely small volumes. Here, the basis of a robust methodology for the fabrication of SPA silicon chips with on-demand ...
Psicodélicos: ¿drogas peligrosas o nuevos tratamientos contra la depresión?
L'article tracta de l´ús de substàncies psicodèliques (al·lucinògenes) per al tractament de la depressió resistent als tractaments habituals. La capacitat que tenen aquestes substàncies d'induir neuroplasticitat sembla ...
Primers resultats del Passaport a la Professió a Farmàcia
Podeu consultar la Vuitena trobada de professorat de Ciències de la Salut completa a: http://hdl.handle.net/2445/66524
Memantine loaded PLGA PEGylated nanoparticles for Alzheimer's disease: in vitro and in vivo characterization
Background: Memantine, drug approved for moderate to severe Alzheimer's disease, has not shown to be fully efective. In order to solve this issue, polylactic-co-glycolic (PLGA) nanoparticles could be a suitable solution ...
Prácticas en empresa: "lecciones" aprendidas
Podeu consultar la Vuitena trobada de professorat de Ciències de la Salut completa a: http://hdl.handle.net/2445/66524
