To access the full text documents, please follow this link: http://hdl.handle.net/2445/69727

Metabolomic insights into the intricate gut microbial-host interaction in the development of obesity and type 2 diabetes
Palau-Rodriguez, Magalí; Tulipani, Sara; Queipo-Ortuño, María Isabel; Urpí Sardà, Mireia; Tinahones, Francisco J.; Andrés Lacueva, Ma. Cristina
Universitat de Barcelona
Gut microbiota has recently been proposed as a crucial environmental factor in the development of metabolic diseases such as obesity and type 2 diabetes, mainly due to its contribution in the modulation of several processes including host energy metabolism, gut epithelial permeability, gut peptide hormone secretion, and host inflammatory state. Since the symbiotic interaction between the gut microbiota and the host is essentially reflected in specific metabolic signatures, much expectation is placed on the application of metabolomic approaches to unveil the key mechanisms linking the gut microbiota composition and activity with disease development. The present review aims to summarize the gut microbial
host co-metabolites identified so far by targeted and untargeted metabolomic studies in humans, in association with impaired glucose homeostasis and/or obesity. An alteration of the co-metabolism of bile acids, branched fatty acids, choline, vitamins (i.e., niacin), purines, and phenolic compounds has been associated so far with the obese or diabese phenotype, in respect to healthy controls. Furthermore, anti-diabetic treatments such as metformin and sulfonylurea have been observed to modulate the gut microbiota or at least their metabolic profiles, thereby potentially affecting insulin resistance through indirect mechanisms still unknown. Despite the scarcity of the metabolomic studies currently available on the microbial
host crosstalk, the data-driven results largely confirmed findings independently obtained from in vitro and animal model studies, putting forward the mechanisms underlying the implication of a dysfunctional gut microbiota in the development of metabolic disorders.
Diabetis no-insulinodependent
Obesitat
Metabòlits
Intestins
Microbiologia
Non-insulin-dependent diabetes
Obesity
Metabolites
Intestines
Microbiology
cc-by (c) Palau-Rodriguez, Magalí et al., 2015
http://creativecommons.org/licenses/by/3.0/es
Article
info:eu-repo/semantics/publishedVersion
Frontiers Media
         

Show full item record

Related documents

Other documents of the same author

Boto Ordóñez, María; Urpí Sardà, Mireia; Queipo-Ortuño, María Isabel; Tulipani, Sara; Tinahones, Francisco J.; Andrés Lacueva, Ma. Cristina
Moreno-Indias, Isabel; Sánchez-Alcoholado, Lidia; Pérez-Martínez, Pablo; Andrés Lacueva, Ma. Cristina; Cardona, Fernando; Tinahones, Francisco J.; Queipo-Ortuño, María Isabel
Mora-Cubillos, X.; Tulipani, Sara; Garcia Aloy, Mar; Bulló, M.; Tinahones, Francisco J.; Andrés Lacueva, Ma. Cristina
Garcia Aloy, Mar; Llorach, Rafael; Urpí Sardà, Mireia; Tulipani, Sara; Salas Salvadó, Jordi; Martínez-González, Miguel Ángel, 1957-; Corella Piquer, Dolores; Fitó, Montserrat; Estruch Riba, Ramon; Serra Majem, Lluís; Andrés Lacueva, Ma. Cristina
Garcia Aloy, Mar; Llorach, Rafael; Urpí Sardà, Mireia; Tulipani, Sara; Salas Salvadó, Jordi; Martínez-González, Miguel Ángel, 1957-; Corella Piquer, Dolores; Fitó, Montserrat; Estruch Riba, Ramon; Serra Majem, Lluís; Andrés Lacueva, Ma. Cristina
 

Coordination

 

Supporters