Universitat de Barcelona
2014-06-13T09:34:14Z
2014-06-13T09:34:14Z
2003-08
2014-06-13T09:34:14Z
The outer membrane permeability of Serratia marcescens was studied by comparing porin-deficient mutants with their parental strains. Omp1-deficient strains were selected by moxalactam resistance, whereas mutants lacking the Omp2 porin were obtained by experimental infection with the SMP2 phage, whose primary receptor is the Omp2 porin. The role of porins was demonstrated in quinolone accumulation assays, where semi-quantitative differences in accumulation were observed. Permeability coefficients to cephaloridine of Omp1 mutants were determined and compared with those of the parental strain. The clinical isolates S. marcescens HCPR1 and 866 showed 30- to 200-fold reduced permeability coefficients when Omp1 porin was absent
Article
Published version
English
Resistència als medicaments; Antibiòtics; Medicaments antibacterians; Serratia marcescens; Drug resistance; Antibiotics; Antibacterial agents; Serratia marcescens
Mary Ann Liebert, Inc.
Reproducció del document publicat a: http://dx.doi.org/10.1089/107662903322286463
Microbial Drug Resistance, 2003, vol. 9, num. 3, p. 257-264
http://dx.doi.org/10.1089/107662903322286463
(c) Mary Ann Liebert, Inc., 2003
