Enantioselective Synthesis of Spiro[indolizidine-1,3 '-oxindoles]

Abstract

A three-step procedure for the enantioselective synthesis of spiro[indolizidine-1,3'-oxindoles], consisting of a stereoselective cyclocondensation reaction between (S)-tryptophanol and a prochiral or racemic 5-oxoester, bromination of the resulting oxazolopiperidone lactam, and a final stereoselective spirocyclization, is reported.

Document Type

Article


Accepted version

Language

English

Publisher

American Chemical Society

Related items

Versió postprint del document publicat a: https://doi.org/10.1021/acs.orglett.71301818

Organic Letters, 2017, vol. 19, num. 15, p. 4050-4053

https://doi.org/10.1021/acs.orglett.71301818

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(c) American Chemical Society , 2017