Cyclocondensation reactions of 2-acyl-3-indoleacetic acid derivatives with phenylglycinol. Enantioselective synthesis of 1-substituted tetrahydro-b-carboline alkaloids

Abstract

Cyclocondensation reactions between a variety of 2‐acyl‐3‐indoleacetic acid derivatives and (R )‐phenylglycinol were studied. Successful results were obtained from N ‐alkyl keto acid derivatives. The resulting tetracyclic lactams provide straightforward access to enantiopure 1‐substituted tetrahydro‐β‐carboline alkaloids.