dc.contributor.author
Rudilla Mateo, Héctor
dc.contributor.author
Fusté i Domínguez, Ester
dc.contributor.author
Cajal Visa, Yolanda
dc.contributor.author
Rabanal Anglada, Francesc
dc.contributor.author
Vinuesa Aumedes, Teresa
dc.contributor.author
Viñas, Miquel
dc.date.issued
2016-11-02T09:16:37Z
dc.date.issued
2016-11-02T09:16:37Z
dc.date.issued
2016-09-12
dc.date.issued
2016-11-02T09:16:42Z
dc.identifier
https://hdl.handle.net/2445/103103
dc.description.abstract
The aim was to explore the antimicrobial activity of a synthetic peptide (AMP38) and its synergy with imipenem against imipenem-resistant Pseudomonas aeruginosa. The main mechanism of imipenem resistance is the loss or alteration of protein OprD. Time-kill and minimal biofilm eradication concentration (MBEC) determinations were carried out by using clinical imipenem-resistant strains. AMP38 was markedly synergistic with imipenem when determined in imipenem-resistant P. aeruginosa. MBEC obtained for the combination of AMP38 and imipenem was of 62.5 μg/mL, whereas the MBEC of each antimicrobial separately was 500 μg/mL. AMP38 should be regarded as a promising antimicrobial to fight MDR P. aeruginosa infections. Moreover, killing effect and antibiofilm activity of AMP38 plus imipenem was much higher than that of colistin plus imipenem.
dc.format
application/pdf
dc.relation
Reproducció del document publicat a: https://doi.org/10.3390/molecules21091223
dc.relation
Molecules, 2016, vol. 21, num. 9, p. 1223
dc.relation
https://doi.org/10.3390/molecules21091223
dc.rights
cc-by (c) Rudilla, Héctor et al., 2016
dc.rights
http://creativecommons.org/licenses/by/3.0/es
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Patologia i Terapèutica Experimental)
dc.subject
Síntesi de pèptids
dc.subject
Peptide synthesis
dc.title
Synergistic antipseudomonal effects of synthetic peptide AMP38 and carbapenems
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
