Universitat de Barcelona
The aim was to explore the antimicrobial activity of a synthetic peptide (AMP38) and its synergy with imipenem against imipenem-resistant Pseudomonas aeruginosa. The main mechanism of imipenem resistance is the loss or alteration of protein OprD. Time-kill and minimal biofilm eradication concentration (MBEC) determinations were carried out by using clinical imipenem-resistant strains. AMP38 was markedly synergistic with imipenem when determined in imipenem-resistant P. aeruginosa. MBEC obtained for the combination of AMP38 and imipenem was of 62.5 μg/mL, whereas the MBEC of each antimicrobial separately was 500 μg/mL. AMP38 should be regarded as a promising antimicrobial to fight MDR P. aeruginosa infections. Moreover, killing effect and antibiofilm activity of AMP38 plus imipenem was much higher than that of colistin plus imipenem.
English
Pseudomonas; Síntesi de pèptids; Pèptids; Biofilms; Antibiòtics; Pseudomonas; Peptide synthesis; Peptides; Biofilms; Antibiotics
MDPI
Reproducció del document publicat a: https://doi.org/10.3390/molecules21091223
Molecules, 2016, vol. 21, num. 9, p. 1223
https://doi.org/10.3390/molecules21091223
cc-by (c) Rudilla, Héctor et al., 2016
http://creativecommons.org/licenses/by/3.0/es
Farmàcia, Tecnologia Farmacèutica i Fisicoquímica [626]
Infermeria de Salut Pública, Salut Mental i Maternoinfantil [901]
Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL) [6740]
Institut de Nanociència i Nanotecnologia (IN2UB) [366]
ISGlobal - Institut de Salut Global de Barcelona [58114]
