Patologia i Terapèutica Experimental: Recent submissions
Now showing items 221-240 of 1057
Reelin regulates the development and synaptogenesis of the layer-specific entorhino-hippocampal connections
Here we examine the role of Reelin, an extracellular protein involved in neuronal migration, in the formation of hippocampal connections. Both at prenatal and postnatal stages, the general laminar and topographic distribution ...
The t-SNAREs syntaxin 1 and SNAP-25 are present on organelles that participate in synaptic vesicle recycling
Syntaxin 1 and synaptosome-associated protein of 25 kD (SNAP-25) are neuronal plasmalemma proteins that appear to be essential for exocytosis of synaptic vesicles (SVs). Both proteins form a complex with synaptobrevin, an ...
Percutaneous, intra-articular, chevron osteotomy (PeICO) for the treatment of mild-to-moderate hallux valgus: a case series
Purpose: Treatment for hallux valgus (HV) remains challenging. Third-generation percutaneous procedures try to reproduce chevron-type osteotomies to replicate their benefits, such as intrinsic stability and reproducibility. ...
Actualización en el tratamiento farmacológico de la artrosis
En la Conferencia de la OARS (Osteoarthritis Research Society, 1996) los medicamentos utilizados en el tratamiento de la artrosis se clasificaron según su mecanismo de acción en fármacos de acción sintomática y/o acción ...
Not so pseudo: the evolutionary history of protein phosphatase 1 regulatory subunit 2 and related pseudogenes
Background: pseudogenes are traditionally considered "dead" genes, therefore lacking biological functions. This view has however been challenged during the last decade. This is the case of the Protein phosphatase 1 regulatory ...
Bacterial adhesion efficiency on implant abutments: a comparative study
The attachment of Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 28213 onto six different materials used to manufacture dental implant abutments was quantitatively determined after 2 and 24 h of contact between ...
Redefining anterior ankle arthroscopic anatomy: medial and lateral ankle collateral ligaments are visible through dorsiflexion and non-distraction anterior ankle arthroscopy
Purpose: A thorough understanding of the arthroscopic anatomy is important to recognise pathological conditions. Although some ankle ligaments have been described as intra-articular structures, no studies have assessed the ...
Evolution of cervical cytologic changes among HIV-infected women with normal cytology in the HAART era.
The influence of HAART on the evolution to cervical squamous intraepithelial lesions (SIL) among HIV(+) women with a normal cytological test in the HAART era was studied. A retrospective cohort study (1997-2005) of ...
TrkB and TrkC signaling are required for maturation and synaptogenesis of hippocampal connections
Recent studies have suggested a role for neurotrophins in the growth and refinement of neural connections, in dendritic growth, and in activity-dependent adult plasticity. To unravel the role of endogenous neurotrophins ...
Mouthrinses: a comparative microbiological study
This study was performed in order to evaluate the efficacy of different mouthrinses whose use is extended in Spain. Six different antiseptic mouthrinses were studied by means of determination of Minimal Inhibitory Concentration ...
Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa
Background: protein Ser/Thr Phosphatase PPP1CC2 is an alternatively spliced isoform of PPP1C that is highly enriched in testis and selectively expressed in sperm. Addition of the phosphatase inhibitor toxins okadaic acid ...
Moderate and severe dental fluorosis in the rural population of Anantapur, India: change in their biological susceptibility?
Dental fluorosis affects the quality of life. A cross-sectional, observational study was conducted in a community affected by endemic fluorosis for several generations with a conserved biological and social environment. ...
miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy
The female mammary gland is a very dynamic organ that undergoes continuous tissue remodeling during adulthood. Although it is well established that the number of menstrual cycles and pregnancy (in this case transiently) ...
Bcl-2 family proteins and cytoskeleton changes involved in DM-1 cytotoxic effect on melanoma cells
Melanoma is one of the most aggressive types of skin cancer and its incidence rate is still increasing. All existing treatments are minimally effective. Consequently, new therapeutic agents for melanoma treatment should ...
The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
Background: the TP53 pathway, in which TP53 and its negative regulator MDM2 are the central elements, has an important role in carcinogenesis, particularly in BRCA1- and BRCA2-mediated carcinogenesis. A single nucleotide ...
αE-catenin-dependent mechanotransduction is essential for proper convergent extension in zebrafish
Cadherin complexes mediate cell-cell adhesion and are crucial for embryonic development. Besides their structural function, cadherin complexes also transduce tension across the junction-actomyosin axis into proportional ...
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination
Activation of the RAS oncogenic pathway, frequently ensuing from mutations in RAS genes, is a common event in human cancer. Recent reports demonstrate that reversible ubiquitination of RAS GTPases dramatically affects their ...
Biochemical, ultrastructural, and reversiblity studies on Huntingtin filaments isolated from mouse and human brain
Huntington's disease (HD) and eight additional inherited neurological disorders are caused by CAG triplet-repeat expansions leading to expanded polyglutamine-sequences in their respective proteins. These triplet-CAG repeat ...
Chronic hypoxia induced ultrastructural changes in the rat adrenal zona glomerulosa
The adrenal cortex plays an important role in adaptation to various forms of stress, including hypoxia. While physiological changes in the aldosterone metabolism during hypoxia have been extensively described, few studies ...
El examen MIR y su contenido en anatomía humana, bioestadística y epidemiología: evolución y accesibilidad para el opositor/a
Fundamentos: El examen MIR constituye actualmente el único medio de selección de candidatos para la formación de médicos especialistas en España. Consta de 260 preguntas (10 de ellas son de reserva) de las distintas ...
