Patologia i Terapèutica Experimental: Enviaments recents
Ara mostrant els elements 241-260 de 1057
Emergence of Amoxicillin-Resistant Variants of Spain(9V)-ST156 Pneumococci Expressing Serotype 11A Correlates with Their Ability to Evade the Host Immune Response
Capsular switching allows pre-existing clones of Streptococcus pneumoniae expressing vaccine serotypes to escape the vaccine-induced immunity by acquisition of capsular genes from pneumococci of a non-vaccine serotype. ...
A highly conserved molecular switch binds MSY-3 to regulate myogenin repression in postnatal muscle
Myogenin is the dominant transcriptional regulator of embryonic and fetal muscle differentiation and during maturation is profoundly down-regulated. We show that a highly conserved 17-bp DNA cis-acting sequence element ...
Overexpression of alpha(1,3)-fucosyltransferase VII is sufficient for the acquisition of lung colonization phenotype in human lung adenocarcinoma HAL-24Luc cells
Metastatic human lung adenocarcinoma HAL-8Luc cells display an enhanced expression of alpha(1,3)-fucosyltransferases (alpha(1,3)-Fuc-Ts) compared with their non-metastatic counterpart HAL-24Luc cells. This correlates with ...
Munc13-1 is a Ca2+-phospholipid-dependent vesicle priming hub that shapes synaptic short-term plasticity and enables sustained neurotransmission
During ongoing presynaptic action potential (AP) firing, transmitter release is limited by the availability of release-ready synaptic vesicles (SVs). The rate of SV recruitment (SVR) to release sites is strongly upregulated ...
Cytotoxicity comparison of Bio C Sealer against multiple root canal sealers
Background: The aim of this study was to compare the cytotoxicity of calcium silicate-based endodontic sealer, Bio-C® Sealer, with other calcium silicate-based sealers: BioRoot¿ RCS, one silicon-based sealer combined with ...
Neuroprotection with Hypothermia and Allopurinol in an animal model of hypoxic-ischemic injury: Is it a gender question?
Abstract Background Hypoxic-ischemic encephalopathy (HIE) is one of the most important causes of neonatal brain injury. Therapeutic hypothermia (TH) is the standard treatment for term newborns after perinatal hypoxic ...
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination
Activation of the RAS oncogenic pathway, frequently ensuing from mutations in RAS genes, is a common event in human cancer. Recent reports demonstrate that reversible ubiquitination of RAS GTPases dramatically affects their ...
Endometrial epithelial cell organoids as tools for studying the CD39 family of enzymes and for validating enzyme inhibitors
Extracellular adenosine triphosphate (ATP) conducts a complex dynamic system of broadly represented cell signaling. Ectonucleotidases are the enzymes with nucleotide hydrolytic ability that regulate ATP levels in physiological ...
Biochemical, ultrastructural, and reversiblity studies on Huntingtin filaments isolated from mouse and human brain
Huntington's disease (HD) and eight additional inherited neurological disorders are caused by CAG triplet-repeat expansions leading to expanded polyglutamine-sequences in their respective proteins. These triplet-CAG repeat ...
Chronic hypoxia induced ultrastructural changes in the rat adrenal zona glomerulosa
The adrenal cortex plays an important role in adaptation to various forms of stress, including hypoxia. While physiological changes in the aldosterone metabolism during hypoxia have been extensively described, few studies ...
El examen MIR y su contenido en anatomía humana, bioestadística y epidemiología: evolución y accesibilidad para el opositor/a
Fundamentos: El examen MIR constituye actualmente el único medio de selección de candidatos para la formación de médicos especialistas en España. Consta de 260 preguntas (10 de ellas son de reserva) de las distintas ...
Macrophages require distinct arginine catabolism and transport systems for proliferation and for activation.
In murine macrophages, as a result of arginine catabolism during activation, citruline isproduced under the effect of IFN-c and LPS, and ornithine and polyamines by IL-4 and IL-10. For proliferation, arginine is required ...
Bcl-2 family proteins and cytoskeleton changes involved in DM-1 cytotoxic effect on melanoma cells
Melanoma is one of the most aggressive types of skin cancer and its incidence rate is still increasing. All existing treatments are minimally effective. Consequently, new therapeutic agents for melanoma treatment should ...
Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons
Human induced pluripotent stem cell (hiPSC) technologies offer a unique resource for modeling neurological diseases. However, iPSC models are fraught with technical limitations including abnormal aggregation and inefficient ...
Feasibility of lumbar puncture in the study of cerebrospinal fluid biomarkers for Alzheimer disease in subjects with Down syndrome
Background: Alzheimer's disease (AD) is the main medical problem in older adults with Down syndrome (DS). Studies of cerebrospinal fluid (CSF) AD biomarkers are limited and the feasibility of lumbar puncture (LP) is ...
The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
Background: the TP53 pathway, in which TP53 and its negative regulator MDM2 are the central elements, has an important role in carcinogenesis, particularly in BRCA1- and BRCA2-mediated carcinogenesis. A single nucleotide ...
Percutaneous, intra-articular, Chevron osteotomy (PeICO) for the treatment of hallux valgus: a cadaveric study
Background: Percutaneous surgery is experiencing sustained growth based on third-generation techniques. This cadaveric study was designed with the main goal of exploring the risk of iatrogenic tendon and neurovascular ...
Expressió gènica en models d'isquèmia cerebral
La isquèmia cerebral pot causar una lesió irreversible al cervell, amb una important pèrdua neuronal a les zones afectades. Entre els primers canvis que es detecten després de la isquèmia hi ha alteracions del patró ...
Cirugía plástica de las malformaciones congénitas del aparato genital: anomalías de diferenciación sexual
Se presenta la necesidad de tratar estas malformaciones congénitas en una unidad hospitalaria en la que el pediatra realiza la labor coordinadora, diagnóstica y de tratamiento médico y el cirujano plástico las plastias ...
Valoración de la aplicación del eLearning en la docencia de Farmacologia
La implementació del eLearning es eficient i està justificada si prèviament s'evoluciona de docència expositiva a docència funcional. Aquesta proporciona informació als docents orientant sobre el seu impacte i eficàcia i ...
