Patologia i Terapèutica Experimental: Recent submissions
Now showing items 181-200 of 1057
Optical control of adenosine A3 receptor signaling: Towards a multimodal phototherapy in psoriasis?
Psoriasis is a long-lasting inflammatory disease primarily characterized by cutaneous and systemic manifestations but also showing multiple comorbidities (i.e., psoriatic arthritis, cardiometabolic diseases, psychological ...
Long-term labeling of hippocampal neural stem cells by a lentiviral vector
Using a lentivirus-mediated labeling method, we investigated whether the adult hippocampus retains long-lasting, self-renewing neural stem cells (NSCs). We first showed that a single injection of a lentiviral vector ...
Histomorphometric analysis of osseointegrated grade V titanium mini transitional implants inEdentulous mandible by backscattered scanning electron microscopy (BS-SEM)
The purpose of this study is to assess the use of grade V titanium mini transitional implants(MTIs) immediately loaded by a temporary overdenture. For this, a histomorphometric analysisof the bone area fraction occupancy ...
Tauroursodeoxycholic bile acid arrests axonal degeneration by inhibiting the unfolded protein response in X-linked adrenoleukodystrophy
The activation of the highly conserved unfolded protein response (UPR) is prominent in the pathogenesis of the most prevalent neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD) and ...
Prognostic value of replication errors on chromosomes 2p and 3p in non-small-cell lung cancer
As chromosomes 2p and 3p are frequent targets for genomic instability in lung cancer, we have addressed whether alterations of simple (CA)n DNA repeats occur in non-small-cell lung cancer (NSCLC) at early stages. We have ...
Comparison of the masticatory force (with 3D models) of complete denture base acrylic resins with reline and reinforcing materials
The reinforcement of acrylic denture base remains problematic. Acrylic prosthesis fractures are commonly observed in prosthodontic practice and have not been reliably resolved. This study compared the resistance to masticatory ...
Transforming growth factor -α expression in rat experimental hepatocarcinogenesis
Growth factors in general and transforming growth factor-alpha in particular have been related to cell proliferation and cell differentiation. This study was designed to clarify the distribution pattem of TGF-alpha in ...
Proteins influencing foam formation in wine and beer: the role of yeast
This review focuses on the role of proteins in the production and maintenance of foam in both sparkling wines and beer. The quality of the foam in beer but especially in sparkling wines depends, among other factors, on the ...
Super-Cationic Peptide Dendrimers¿Synthesis and Evaluation as Antimicrobial Agents
Microbial infections are a major public health concern. Antimicrobial peptides (AMPs) have been demonstrated to be a plausible alternative to the current arsenal of drugs that has become inefficient due to multidrug ...
Acinetobacter sp: importància com a patogen nosocomial en l'actualitat
El gènere Acinetobacter està format per bacils gramnegatius immòbils àmpliament distribuïts en la natura. Des de la seva descripció, els membres d'aquest gènere han patit nombrosos canvis taxonòmics, en part a causa de ...
Therapeutic strategies involving survivin inhibition in cancer
Survivin is a small protein that belongs to the inhibitor of apoptosis protein family. It is abundantly expressed in tumors compared with adult differentiated tissues, being associated with poor prognosis in many human ...
The level of caveolin-1 expression determines response to TGF-ß as a tumor suppressor in hepatocellular carcinoma cells
Hepatocellular carcinoma (HCC) is a heterogeneous tumour associated with poor prognostic outcome. Caveolin-1 (CAV1), a membrane protein involved in the formation of caveolae, is frequently overexpressed in HCC. Transforming ...
The voltage-dependent K+ channels Kv1.3 and Kv1.5 in human cancer
Voltage-dependent K+ channels (Kv) are involved in a number of physiological processes, including immunomodulation, cell volume regulation, apoptosis as well as differentiation. Some Kv channels participate in the proliferation ...
Cord blood-derived neuronal cells by ectopic expression of SOX2 and c-MYC
The finding that certain somatic cells can be directly converted into cells of other lineages by the delivery of specific sets of transcrip- tion factors paves the way to novel therapeutic applications. Here we show that ...
Rem2 GTPase maintains survival of human embryonic stem cells as well as enhancing reprogramming by regulating p53 and cyclin D1
Human pluripotent stem cells, such as embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), have the unique abilities of differentiation into any cell type of the organism (pluripotency) and indefinite ...
Synapse elimination activates a coordinated homeostatic presynaptic response in an autaptic circuit
The number of synapses present in a neuronal circuit is not fixed. Neurons must compensate for changes in connectivity caused by synaptic pruning, learning processes or pathological conditions through the constant adjustment ...
The ADORA1 mutation linked to early-onset Parkinson's disease alters adenosine A1-A2A receptor heteromer formation and function
Adenosine modulates neurotransmission through inhibitory adenosine A1 receptors (A1Rs) and stimulatory A2A receptors (A2ARs). These G protein-coupled receptors are involved in motor function and related to neurodegenerative ...
Kinematic and Kinetic Adaptations to Step Cadence ModulationDuringWalking in Healthy Adults
Walking cadence is commonly adjusted in sport and rehabilitation, yet itseffects on spatiotemporal gait parameters and regional plantar pressure distribution undercontrolled speed conditions remain incompletely characterized. ...
Single-cell transcriptome conservation in cryopreserved cells and tissues
A variety of single-cell RNA preparation procedures have been described. So far, protocols require fresh material, which hinders complex study designs. We describe a sample preservation method that maintains transcripts ...
Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1
Excitotoxicity, a critical process in neurodegeneration, induces oxidative stress and neuronal death through mechanisms largely unknown. Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated ...
