Patologia i Terapèutica Experimental: Enviaments recents
Ara mostrant els elements 61-80 de 1057
The EMT signaling pathways in endometrial carcinoma
Endometrial cancer (EC) is the most common gynecologic malignancy of the female genital tract and the fourth most common neoplasia in women. In EC, myometrial invasion is considered one of the most important prognostic ...
Actualización en la prevención de las úlceras gastroduodenales inducidas por antiinflamatorios no esteroideos y sus complicaciones
Los antiinflamatorios no esteroideos (AINE) son ampliamente prescritos para el tratamiento de cuadros clínicos de dolor y procesos inflamatorios. No obstante, producen efectos adversos gastrointestinales que pueden ser ...
Involvement of Bax protein in the prevention of glucocorticoid-induced thymocytes apoptosis by melatonin
The antiapoptotic effect of melatonin has been described in several systems. In this study, the antagonistic effect of the methoxyindole on dexamethasone-induced apoptosis in mouse thymocytes was examined. Melatonin decreased ...
Excitadores ganglionares como reactivo farmacológico
La farmacología del ganglio vegetativo es de gran interés teórico y práctico. Conocemos desde hace mucho tiempo el mecanismo colinérgico de la transmisión ganglionar vegetativa. La acetilcolina estimula el ganglio cuando ...
Neuron-specific alterations in signal transduction pathways associated with Alzheimer's disease
The hallmarks of sporadic Alzheimer's disease (AD) are extracellular amyloid deposits, intracellular neurofibrillary tangles (NFTs), and neuronal death. Hyperphosphorylation of tau is a key factor in the generation of NFTs. ...
CARD14E138A signalling in keratinocytes induces TNF-dependent skin and systemic inflammation
To investigate how the CARD14E138A psoriasis-associated mutation induces skin inflammation, a knock-in mouse strain was generated that allows tamoxifen-induced expression of the homologous Card14E138A mutation from the ...
Reporting randomised clinical trials of analgesics after traumatic or orthopaedic surgery is inadequate: a systematic review.
Background Several randomised clinical trials (RCTs) of analgesics in postoperative pain after traumatic or orthopaedic surgery (TOS) have been published, but no studies have assessed the quality of these reports. We aimed ...
Medium-long-term clinical and radiographic outcomes of minimally invasive distal metatarsal metaphyseal osteotomy (DMMO) for central primary metatarsalgia: do maestro criteria have a predictive value in the preoperative planning for this percutaneous technique?
Background: The purpose of this prospective study was first to evaluate the safety and effectiveness of Minimally Invasive Distal Metatarsal Metaphyseal Osteotomy (DMMO) in treating central metatarsalgia, identifying ...
Patología del quinto radio. Parte I: Anatomía y Biomecánica
Se realiza una revisión de las características anatómicas y biomecánicas del quinto radio formado por el quinto metatarsiano y las tres falanges correspondientes.
Etiología de las infecciones del tracto urinario y sensibilidad de los uropatógenos a los antimicrobianos
El tratamiento antibiótico de la infección urinaria en el adulto se realiza habitualmente de forma empírica, siendo excepcional la realización de urocultivo. La elección del antibiótico se sustenta en los resultados de las ...
Experimental study on radioactive pathways of hypodermically injected technetium-99m
The objective of this study was to investigate the biological substrate of radioactive pathways of migration of hypodermically injected 99mTc into points of low electrical resistance. Sixteen anesthetized adult male beagles ...
Disposición del sistema trabecular esclero-corneal en fetos humanos
Disposición del sistema trabecular esclero-córneal en fetos humanos: en el presente trabajo mediante el estudio con el microscopio óptico y de barrido de ojos de 20 fetos humanos de 33 a 326 mm. (7 a 36 semanas de gestación), ...
The lateral fibulotalocalcaneal ligament complex: an ankle stabilizing isometric structure
Purpose: Ankle lateral collateral ligament complex has been the focus of multiple studies. However, there are no specific descriptions of how these ligaments are connected to each other as part of the same complex. The aim ...
Transcutaneous Electrical Neuromodulation of the Cervical Spinal Cord Depends Both on the Stimulation Intensity and the Degree of Voluntary Activity for Training. A Pilot Study
Electrical enabling motor control (eEmc) through transcutaneous spinal cord stimulation offers promise in improving hand function. However, it is still unknown which stimulus intensity or which muscle force level could be ...
Situación del dolor en los hospitales de Cataluña
En el ámbito hospitalario, diferentes estudios en todo el mundo han demostrado que el dolor es un problema relevante. La importancia de un tratamiento adecuado del dolor hospitalario ha sido reconocida de forma institucional ...
Comparative gene expression profiling between human cultured myotubes and skeletal muscle tissue
Background: a high-sensitivity DNA microarray platform requiring nanograms of RNA input facilitates the application of transcriptome analysis to individual skeletal muscle (SM) tissue samples. Culturing myotubes from ...
Immediate small-diameter implants as abutments for an overdenture in the edentulous atrophic mandible: report of immersion endoscopic bone in vivo, and histologic bone-implant evaluation after 6 months of function
The aim of this report was to endoscopically evaluate bone quality in vivo in the immediate installation of temporary small-diameter implants, and again after 6 months of function, through an attachments system for ...
Melatonin inhibits glucocorticoid receptor nuclear translocation in mouse thymocytes
The antiapoptotic effect of melatonin (MEL) has been described in several systems. In particular, MEL inhibits glucocorticoid-mediated apoptosis. Our group previously demonstrated that in the thymus, MEL inhibits the release ...
Utilidad de las técnicas de biología molecular en el diagnóstico de las infecciones cutáneas
Las infecciones cutáneas pueden ser producidas por una amplia variedad de microorganismos que proceden, fundamentalmente, de la propia microbiota de la piel y de las mucosas, aunque también del medio ambiente. Estas ...
Proteolysis of SNAP-25 by types E and A botulinal neurotoxins
Clostridial neurotoxins, tetanus toxin (TeTx) and the seven related but serologically distinct botulinal neurotoxins (BoNT/A to BoNT/G), are potent inhibitors of synaptic vesicle exocytosis in nerve endings. Recently it ...
