Patologia i Terapèutica Experimental: Enviaments recents
Ara mostrant els elements 141-160 de 1057
"Randomización": significado de la aleatoriedad en la investigación clínica
Se comenta el significado de la selección o asignación aleatoria, randomización, en la investigación clínica. Se enumeran las bases teóricas, las implicaciones prácticas de la aleatoriedad, y su influencia en el diseño de ...
Elements of morphology: Standard terminology for the teeth and classifying genetic dental disorders
Dental anomalies occur frequently in a number of genetic disorders and act as major signs in diagnosing these disorders. We present definitions of the most common dental signs and propose a classification usable as a ...
Ultrastructural Imaging of Activity-Dependent Synaptic Membrane-Trafficking Events in Cultured Brain Slices
Electron microscopy can resolve synapse ultrastructure with nanometer precision, but the capture of time-resolved, activity-dependent synaptic membrane-trafficking events has remained challenging, particularly in functionally ...
All-optical electrophysiology for high-throughput functional characterization of a human iPSC-Derived motor neuron model of ALS
Human induced pluripotent stem cell (iPSC)-derived neurons are an attractive substrate for modeling disease, yet the heterogeneity of these cultures presents a challenge for functional characterization by manual patch-clamp ...
Enfermedad neuromuscular oculocraniosomática de Kearns Sayre: a propósito de tres casos
Se describen tres pacientes de 9. 7 y 28 años, afectos del síndrome neuromuscular oculocraneosomático de Kearns-Sayre. A dichos enfermos se les ha practicado T.C. cerebral E.R.G.. potenciales evocados visuales, acústicos ...
Sonic hedgehog promotes generation and maintenance of human forebrain Olig2 progenitors
Function of oligodendrocytes (OLs), myelin forming cells in the CNS, is disrupted in demyelinating diseases such as periventricular leukomalacia or multiple sclerosis. It is, thus, important to better understand factors ...
Ocular pain and discomfort after advanced surface ablation (ASA): an ignored complaint
Purpose: Laser vision correction is one of the most commonly performed elective surgical procedures in ophthalmology. Generally, discomfort besides pain (photophobia, burning sensation, tearing, and foreign body sensation) ...
Molecular Interactions of Prodiginines with the BH3 Domain of Anti-Apoptotic Bcl-2 Family Members.
Prodigiosin and obatoclax, members of the prodiginines family, are small molecules with anti-cancer properties that are currently under preclinical and clinical trials. The molecular target(s) of these agents, however, is ...
Study of the protein complex, pore diameter, and pore-forming activity of the Borrelia burgdorferi P13 porin
P13 is one of the major outer membrane proteins of Borrelia burgdorferi. Previous studies described P13 as a porin. In the present study some structure and function aspects of P13 were studied. P13 showed according to lipid ...
Evolución del consumo de fármacos antiparkinsonianos en España
Introducción: en los últimos años se han comercializado nuevos fármacos antiparkinsonianos y ha existido una polémica sobre la seguridad de algunos de ellos. Objetivo: analizar la evolución del consumo de los fármacos ...
Cervical electrical neuromodulation effectively enhances hand motor output in healthy subjects by engaging a use-dependent intervention
Electrical enabling motor control (eEmc) through transcutaneous spinal cord stimulation is a non-invasive method that can modify the functional state of the sensory-motor system. We hypothesize that eEmc delivery, together ...
Anatomy of the inferior extensor retinaculum and its role in lateral ankle ligament reconstruction: a pictorial essay
The inferior extensor retinaculum (IER) is an aponeurotic structure, which is in continuation with the anterior part of the sural fascia. The IER has often been used to augment the reconstruction of the lateral ankle ...
Anomalías dentarias: prevalencia en relación con patologías sistémicas en una población infantil de Mérida, Venezuela
Las anomalías dentarias se producen por alteraciones que afectan el proceso normal de odontogénesis. Pueden afectar el número, tamaño, forma y estructura de los dientes. El objetivo del presente trabajo fue determinar la ...
A novel empeROR of pancreatic malignancy
How pancreatic cancer cells acquire tumor initiating capacities remains poorly understood. A recent study by Yamazaki et al (2023) uncovers a crucial, targetable role of tyrosine kinase-like orphan receptor (ROR1) in PDAC ...
Protocolo del tratamiento quirúrgico del labio leporino
Se presenta nuestro protocolo del tratamiento quirúrgico del labio leporino en que practicamos la corrección quirúrgica de la hendidura del labio a los seis meses de edad, si se trata de una fisura de labio unilateral. En ...
Analysis of protein-coding mutations in hiPSCs and their possible role during somatic cell reprogramming
Recent studies indicate that human-induced pluripotent stem cells contain genomic structural variations and point mutations in coding regions. However, these studies have focused on fibroblast-derived human induced pluripotent ...
Motivational valence is determined by striatal melanocortin 4 receptors
It is critical for survival to assign positive or negative valence to salient stimuli in a correct manner. Accordingly, harmful stimuli and internal states characterized by perturbed homeostasis are accompanied by discomfort, ...
Neuronal induction of the immunoproteasome in Huntington's disease
Huntington's disease (HD) inclusions are stained with anti-ubiquitin and anti-proteasome antibodies. This, together with proteasome activity studies on transfected cells, suggest that an impairment of the ubiquitin-proteasome ...
The tumor suppressor CYLD regulates the p53 DNA damage response
The tumour suppressor CYLD is a deubiquitinase previously shown to inhibit NF-κB, MAP kinase and Wnt signalling. However, the tumour suppressing mechanisms of CYLD remain poorly understood. Here we show that loss of CYLD ...
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination
Activation of the RAS oncogenic pathway, frequently ensuing from mutations in RAS genes, is a common event in human cancer. Recent reports demonstrate that reversible ubiquitination of RAS GTPases dramatically affects their ...
