Institut de Biomedicina (IBUB): Recent submissions
Now showing items 241-260 of 331
Reactive oxygen species activate the Drosophila TNF receptor Wengen for damage-induced regeneration
Tumor necrosis factor receptors (TNFRs) control pleiotropic pro-inflammatory functions that range from apoptosis to cell survival. The ability to trigger a particular function will depend on the upstream cues, association ...
Serotonin is involved in the psychostimulant and hypothermic effect of 4-methylamphetamine in rats.
4-Methylamphetamine (4-MA) has recently emerged as a designer drug of abuse in Europe and it is consumed always with amphetamine. There have been reported some deaths and non-fatal intoxications related to 4-MA. We ...
Fighting the Influenza A virus. New scaffolds and therapeutic targets
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/120717
miR-146a targets Fos expression in human cardiac cells
miR-146a is a microRNA whose transcript levels are induced in the heart upon activation of NF-kappaB, a transcription factor induced by pro-inflammatory molecules strongly related to the pathogenesis of cardiac disorders. ...
Ask1 and Akt act synergistically to promote ROS-dependent regeneration in Drosophila
How cells communicate to initiate a regenerative response after damage has captivated scientists during the last few decades. It is known that one of the main signals emanating from injured cells is the Reactive Oxygen ...
Comprehensive analysis of the effective and intra-particle diffusion of weakly retained compounds in silica hydrophilic interaction liquid chromatography columns
A detailed analysis of intra-particle volumes and layer thicknesses and their effect on the diffusion of solutes in hydrophilic interaction liquid chromatography (HILIC) was made. Pycnometric measurements and the retention ...
Modulating Ligand Dissociation through Methyl Isomerism in Accessory Sites: Binding of Retinol to Cellular Carriers
Due to the poor aqueous solubility of retinoids, evolution has tuned their binding to cellular proteins to address specialized physiological roles by modulating uptake, storage, and delivery to specific targets. With the ...
The cytoplasmic LIM domain protein Espinas contributes to photoreceptor layer selection in the visual system
One of the central questions in neurobiology is how neurons discriminate between one another during circuit assembly. A common strategy of many nervous systems is the organization of brain regions in layers, to facilitate ...
The splicing factor SF3B1 is involved in brown adipocyte thermogenic activation
The ability of alternative splicing mechanisms to control gene expression is increasingly being recognized as relevant for adipose tissue function. The expression of SF3B1, a key component of the SF3B complex directly ...
The Eighth Data Release of the Sloan Digital Sky Survey: First Data from SDSS-III
The Sloan Digital Sky Survey (SDSS) started a new phase in 2008 August, with new instrumentation and new surveys focused on Galactic structure and chemical evolution, measurements of the baryon oscillation feature in the ...
Controlling the Ambiphilic nature of sigma-arylpalladium intermediates in intramolecular cyclization reactions
The reactivity of main group organometallics, such as organolithium compounds (RLi) and Grignard reagents (RMgX), is quite straightforward. In these species the R group usually exhibits nucleophilic reactivity without any ...
Methods for Assessing the Effects of LXR Agonists on Macrophage Bacterial Infection
Macrophages are phagocytic cells that actively engulf and kill microorganisms within a specialized phagolysosomal system. Several pathogenic bacteria, however, actively co-opt host mechanisms and escape from microbial ...
Brown adipose tissue bioenergetics: a new methodological approach
The rediscovery of brown adipose tissue (BAT) in humans and its capacity to oxidize fat and dissipate energy as heat has put the spotlight on its potential as a therapeutic target in the treatment of several metabolic ...
Tryptophanol-derived oxazolopiperidone lactams: identification of a hit compound as NMDA receptor antagonist
N-Methyl-D-Aspartate (NMDA) receptors are neuronal ionotropic channels that play an important role in memory and learning processes. Their exacerbated activation leads to neuron death by necrosis or apoptosis in a phenomenon ...
Gene regulatory dynamics during the development of a paleopteran insect, the mayfly Cloeon dipterum
The evolution of insects has been marked by the appearance of key body plan innovations that promoted the outstanding ability of this lineage to adapt to new habitats, boosting the most successful radiation in animals. To ...
The secreted autotransporter toxin (Sat) does not act as a virulence factor in the probiotic Escherichia coli strain Nissle 1917
BACKGROUND: Escherichia coli Nissle 1917 (EcN) is a probiotic used in the treatment of intestinal diseases. Although it is considered safe, EcN is closely related to the uropathogenic E. coli strain CFT073 and contains ...
Tumor promoting effects of CD95 signalling in chemoresistant cells
Background: CD95 is a death receptor controlling not only apoptotic pathways but also activating mechanisms promoting tumor growth. During the acquisition of chemoresistance to oxaliplatin there is a progressive loss of ...
Understanding the mechanism of direct activation of AMP-kinase: Towards a fine allosteric tuning of the kinase activity
This research deals with the regulation of the AMPK activity by direct activators, such as compound A-769662. AMPK is a key enzyme to maintain the cellular energy homeostasis, as it regulates the levels of ATP, being an ...
Constraints on deviations from ΛCDM within Horndeski gravity.
Recent anomalies found in cosmological datasets such as the low multipoles of the Cosmic Microwave Background or the low redshift amplitude and growth of clustering measured by e.g., abundance of galaxy clusters and redshift ...
Neuroprotective effects of the multitarget agent AVCRI104P3 in brain of middle-aged mice
Molecular factors involved in neuroprotection are key in the design of novelmultitarget drugs in aging and neurodegeneration. AVCRI104P3 is a huprine derivative that exhibits potent inhibitory effects on human AChE, BuChE, ...
