Institut de Biomedicina (IBUB): Enviaments recents
Ara mostrant els elements 221-240 de 331
NMDA receptor antagonists reduce amyloid-β deposition by modulating calpain-1 signaling and autophagy, rescuing cognitive impairment in 5XFAD mice
Overstimulation of N-methyl-D-aspartate receptors (NMDARs) is the leading cause of brain excitotoxicity and often contributes to neurodegenerative diseases such as Alzheimer's Disease (AD), the most common form of dementia. ...
Assessing the contribution of genes involved in monogenic bone disorders to the etiology of atypical femoral fractures
Background: Recent studies suggested that genetic variants associated with monogenic bone disorders were involved in the pathogenesis of atypical femoral fractures (AFF). Here, we aim to identify rare genetic variants by ...
13 C metabolic Flux analysis shows that resistin impairs the metabolic response to insulin in L6E9 myotubes.
Background It has been suggested that the adipokine resistin links obesity and insulin resistance, although how resistin acts on muscle metabolism is controversial. We aimed to quantitatively analyse the effects of resistin ...
Cell death in regeneration and cell turnover: lessons from planarians and Drosophila
Programmed cell death plays a crucial role during tissue turnover in all animal species, and it is also essential during regeneration, serving as a key signalling mechanism to promote tissue repair and regrowth. In freshwater ...
A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice
Alzheimer's disease (AD) is the leading cause of dementia. Non-competitive N-Methyl-D-aspartate (NMDA) receptor antagonist memantine improved cognition and molecular alterations after preclinical treatment. Nevertheless, ...
Antimicrobial promotion of pig growth is associated with tissue-specific remodeling of bile acid signature and signaling
The spread of bacterial resistance to antimicrobials (AMA) have intensified efforts to discontinue the non-therapeutic use of AMA in animal production. Finding alternatives to AMA, however, is currently encumbered by the ...
The Endocannabinoid System as a Target in Cancer: Status and Future Perspectives
The endocannabinoid system (ECS) represents a complex network of different molecules as cannabinoid receptors, endocannabinoid ligands, and the enzymatic machinery that drives their metabolism, as well as cells and pathways ...
Role of PheE15 gate in ligand entry and nitric oxide detoxification function of Mycobacterium tuberculosis truncated hemoglobin N
The truncated hemoglobin N, HbN, of Mycobacterium tuberculosis is endowed with a potent nitric oxide dioxygenase (NOD) activity that allows it to relieve nitrosative stress and enhance in vivo survival of its host. Despite ...
Parkinson’s disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration
A deeper understanding of early disease mechanisms occurring in Parkinson's disease (PD) is needed to reveal restorative targets. Here we report that human induced pluripotent stem cell (iPSC)-derived dopaminergic neurons ...
Synthesis, in vitro profiling, and in vivo efficacy studies of a new family of multitarget anti-Alzheimer compounds
Simultaneous modulation of several targets or pathological events with a key pathogenic role is a promising strategy to tackle thus far difficult-to-cure or incurable multifactorial diseases, such as Alzheimer's disease ...
Dose and time-dependent selective neurotoxicity induced by mephedrone in mice.
Mephedrone is a drug of abuse marketed as 'bath salts'. There are discrepancies concerning its long-term effects. We have investigated the neurotoxicity of mephedrone in mice following different exposition schedules. ...
The UBA-UIM domains of USP25 regulate the enzyme ubiquitination state and modulate substrate recognition
USP25m is the muscle isoform of the deubiquitinating (DUB) enzyme USP25. Similarly to most DUBs, data on USP25 regulation and substrate recognition is scarce. In silico analysis predicted three ubiquitin binding domains ...
ADGRL3 (LPHN3) variants predict substance use disorder
Genetic factors are strongly implicated in the susceptibility to develop externalizing syndromes such as attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder, conduct disorder, and substance use ...
In search of radical transformations from metal enolates. Direct reactions of N‑acyl-1,3-oxazolidin-2-ones with TEMPO catalyzed by copper(II) acetate
The direct reactions of a diverse range of N-acyl-1,3-oxazolidin-2-ones with TEMPO, catalyzed by copper(II) acetate and 4,7-dimethyl-1,10-phenanthroline without the need for any base, are herein described. These reactions ...
Synthetic approaches towards the Lycopodium alkaloids
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/63704
Synthesis of cinacalcet: an enantiopure active pharmaceutical ingredient (API)
Cinacalcet hydrochloride is the only approved drug acting as calcimimetic, a new class of compds. used in the therapy of secondary hyperparathyroidism and parathyroid carcinoma. Several generic drug manufacturers and ...
A near-infrared light-activatable Ru(II)-coumarin photosensitizer active under hypoxic conditions
Photodynamic therapy (PDT) represents a promising approach for cancer treatment. However, the oxygen dependency of PDT to generate reactive oxygen species (ROS) hampers its therapeutic efficacy, especially against hypoxic ...
Effects of MDPV on dopamine transporter regulation in male rats. Comparison with cocaine.
RATIONALE: MDPV (3,4-methylenedioxypyrovalerone) is a synthetic cathinone present in bath salts. It is a powerful psychostimulant and blocker of the dopamine transporter (DAT), like cocaine. It is known that acute exposure ...
Enantio- and Diastereoconvergent Cyclocondensation Reactions: Synthesis of Enantiopure cis-Decahydroquinolines.
Up to four stereocenters with a well-defined configuration are generated in a single synthetic step by the cyclocondensation of (R)-phenylglycinol or (1S,2R)-1-amino-2-indanol with stereoisomeric mixtures (racemates, meso ...
Parameter Splitting in dark energy: is dark energy the same in the background and in the cosmic structures?
We perform an empirical consistency test of General Relativity/dark energy by disentangling expansion history and growth of structure constraints. We replace each late-universe parameter that describes the behavior of dark ...
