Metabolic Singularities in Microsatellite-Stable Colorectal Cancer: Identifying Key Players in Immunosuppression to Improve the Immunotherapy Response. 

Gorría, Teresa; Sierra-Boada, Marina; Rojas, Mariam; Figueras, Carolina; Marín Martínez, Silvia; Madurga Díez, Sergio; Cascante i Serratosa, Marta; Maurel Santasusana, Joan (Data de publicació: 2026-03-03)

Although immune checkpoint inhibitor (ICI) therapy is currently the standard of care in microsatellite-unstable (MSI) metastatic colorectal cancer (CRC), ICI therapy, alone or in combination with other therapies, is not a ...

Polo-like kinase 1 inhibitors in refractory colorectal cancer: deciphering the myth of synthetic lethality 

Rojas, Mariam; Gonzalez, Laura; Cascante i Serratosa, Marta; Maurel Santasusana, Joan (Data de publicació: 2026-02-02)

Metastatic colorectal cancer (mCRC) remains a highly lethal disease because resistance to chemotherapy and targeted agents—including anti-VEGF and anti-EGFR therapies—emerges rapidly and universally. In RAS‑mutant mCRC, ...

Metabolic plasticity drives specific mechanisms of chemotherapy and targeted therapy resistance in metastatic colorectal cancer 

Rojas, Mariam; Manzi, Malena; Madurga Díez, Sergio; García Velásquez, Fernando Enrique; Romero, Maira Alejandra; Marín Martínez, Silvia; Cascante i Serratosa, Marta; Maurel Santasusana, Joan (Data de publicació: 2026-01-29)

Microsatellite-stable metastatic colorectal cancer (MSS mCRC) is currently treated with chemotherapy and targeted agents based on RAS and BRAF mutational status. Although these therapies offer initial benefit, most patients ...

Transcriptomic profiling of endothelial progenitor cells in post-COVID-19 patients: Insights at 3- and 6-month post-infection 

Poyatos Dorado, Paula; Gratacòs-Aurich, Miquel; Aguilar, Daniel; Luque, Neus; Bonnin Vilaplana, Marc; Eizaguirre, Saioa; Cascante i Serratosa, Marta; Orriols Martínez, Ramon; Tura-Ceide, Olga (Data de publicació: 2026-01-27)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused significant global morbidity since 2019. Long COVID, characterized by persistent symptoms after acute infection, may involve endothelial injury. We ...

Design of a true bivalent ligand with picomolar affinity for a G protein-coupled receptor homodimer 

Pulido, Daniel; Casadó Anguera, Verònica; Pérez-Benito, Laura; Moreno Guillén, Estefanía; Cordomí, Arnau; López, Laura; Cortés Tejedor, Antonio; Ferré, Sergi; Pardo, Leonardo; Casadó, Vicent; Royo Expósito, Miriam (Data de publicació: 2026-01-23)

Bivalent ligands have emerged as chemical tools to study G protein-coupled receptor dimers. Using a combination of computational, chemical, and biochemical tools, here we describe the design of bivalent ligand 13 with high ...

Towards biomimetic electrochromatography: Fast method for the Abraham's characterization of solute-solvent interactions in micellar and microemulsion electrokinetic systems 

Idrees, Rabia; Subirats i Vila, Xavier; Amézqueta, Susana; Rosés Pascual, Martí (Data de publicació: 2026-01-16)

This study presents a fast method for the characterization of solute-solvent interactions in micellar and microemulsion electrokinetic chromatography based on the linear solvation energy relationships proposed by Abraham. ...

Intergenerational effects of maternal childhood maltreatment on newborns' stress regulation: The role of maternal depressive symptoms 

San Martín-Gonzalez, Nerea; Moya-Higueras, Jorge; Eixarch Roca, Elisenda; Castro-Quintas, Águeda; Marques-Feixa, Laia; Crispi Brillas, Fàtima; Daura-Corral, Maria; de la Fuente-Tomás, Lorena; Monteserín-García, José Luis; García Portilla, María Paz; Fañanás Saura, Lourdes (Data de publicació: 2024-12-03)

Background: Maternal childhood maltreatment (CM) has been repeatedly associated with negative offspring's emotional outcomes. The dysregulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis has emerged as the main ...

Parameter Splitting in dark energy: is dark energy the same in the background and in the cosmic structures? 

Bernal Mera, José Luis; Verde, Licia; Cuesta Vázquez, Antonio José (Data de publicació: 2019-01-23)

We perform an empirical consistency test of General Relativity/dark energy by disentangling expansion history and growth of structure constraints. We replace each late-universe parameter that describes the behavior of dark ...

The Eighth Data Release of the Sloan Digital Sky Survey: First Data from SDSS-III 

Aihara, Hiroaki; Allende Prieto, Carlos; An, Deokkeun; Anderson, Scott F.; Aubourg, Eric; Balbinot, Eduardo; Beers, Timothy C.; Berlind, Andreas A.; Bickerton, Steven J.; Bizyaev, Dmitry; Blanton, Michael R.; Bochanski, John J.; Bolton, Adam S.; Bovy, Jo; Brandt, W. N.; Brinkmann, Jon; Brown, Peter J.; Brownstein, Joel R.; Busca, Nicolás G.; Campbell, Heather; Carr, Michael A.; Chen, Yanmei; Chiappini, Cristina; Comparat, Johan; Connolly, Natalia; Cortes, Marina; Croft, Rupert A. C.; Cuesta, Antonio J.; Da Costa, Luiz A. N.; Davenport, James R. A.; Dawson, Kyle S.; Dhital, Saurav; Ealet, Anne; Ebelke, Garrett L.; Edmondson, Edward M.; Eisenstein, Daniel J.; Escoffier, Stephanie; Esposito, Massimiliano; Miralda Escudé, Jordi; Verde, Licia (Data de publicació: 2017-02-23)

The Sloan Digital Sky Survey (SDSS) started a new phase in 2008 August, with new instrumentation and new surveys focused on Galactic structure and chemical evolution, measurements of the baryon oscillation feature in the ...

The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: measurements of the growth of structure and expansion rate at z = 0.57 from anisotropic clustering 

Reid, Beth A.; Samushia, Lado; White, Martin; Percival, Will J.; Manera, Marc; Padmanabhan, Nikhil; Ross, Ashley J.; Sánchez, Ariel G.; Bailey, Stephen; Bizyaev, Dmitry; Bolton, Adam S.; Brewington, Howard; Brinkmann, Jon; Brownstein, Joel R.; Cuesta, Antonio J.; Eisenstein, Daniel J.; Gunn, James E.; Honscheid, Klaus; Malanushenko, Elena; Malanushenko, Viktor; Maraston, Claudia; McBride, Cameron K.; Muna, Demetri; Nichol, Robert C.; Oravetz, Daniel; Pan, Kaike; de Putter, Roland; Roe, Natalie A.; Ross, Nicholas P.; Schlegel, David J.; Schneider, Donald P.; Seo, Hee-Jong; Shelden Bradley, Alaina; Sheldon, Erin S.; Simmons, Audrey; Skibba, Ramin; Snedden, Stephanie; Swanson, Molly E. C.; Thomas, Daniel; Verde, Licia (Data de publicació: 2017-02-22)

We analyse the anisotropic clustering of massive galaxies from the Sloan Digital Sky Survey III Baryon Oscillation Spectroscopic Survey (BOSS) Data Release 9 (DR9) sample, which consists of 264 283 galaxies in the redshift ...

The urea cycle of rat white adipose tissue 

Arriarán, Sofía; Agnelli, Silvia; Remesar Betlloch, Xavier; Fernández López, José Antonio; Alemany, Marià, 1946- (Data de publicació: 2016-02-22)

White adipose tissue (WAT) contains a powerful metabolic machinery related to energy metabolism and partition. The adaptive, regulatory, size and structural variety of WAT agrees with this control role. However, its nitrogen ...

Pro-osteoporotic miR-320a impairs osteoblast function and induces oxidative stress 

Ugarte, Laura de; Balcells Comas, Susana; Nogués Solán, Xavier; Grinberg Vaisman, Daniel Raúl; Díez Pérez, Adolfo; Garcia Giralt, Natalia (Data de publicació: 2019-03-14)

MicroRNAs (miRNAs) are important regulators of many cellular processes, including the differentiation and activity of osteoblasts, and therefore, of bone turnover. MiR-320a is overexpressed in osteoporotic bone tissue but ...

Liquid fructose supplementation in LDL-R−/− mice fed a western-type diet enhances lipid burden and atherosclerosis despite identical calorie consumption 

Hutter, Natalia; Baena Muñoz, Miguel; Sangüesa Puigventós, Gemma; Dávalos, Albert; Latasa, María Jesús; Escolà Gil, Joan Carles; Sánchez Peñarroya, Rosa M.; Roglans i Ribas, Núria; Alegret i Jordà, Marta; Laguna Egea, Juan Carlos (Data de publicació: 2016-01-18)

Background Studies on humans have related the high consumption of fructose, especially in the form of sugar-sweetened beverages, to obesity, fatty liver, and hypercholesterolemia, all risk factors for atherosclerosis, and ...

Pharmacological inhibition of soluble epoxide hydrolase protects cognitive impairment in a Niemann-Pick mice model 

Companys Alemany, Júlia; Cozar, Mónica; Grinberg Vaisman, Daniel Raúl; Vilageliu i Arqués, Lluïsa; Codony Gisbert, Sandra; Vázquez Cruz, Santiago; Pallàs i Llibería, Mercè, 1964-; Griñán Ferré, Christian (Data de publicació: 2020-09-16)

Niemann-Pick type C (NPC) disease is a childhood autosomal recessive inherited rare neurodegenerative disease characterized by accumulation of cholesterol and glycosphingolipids and where the autophagy-lysosome system and ...

Robustness of cosmic neutrino background detection in the cosmic microwave background 

Audren, Benjamin; Bellini, Emilio; Cuesta, Antonio J.; Gontcho, Satya Gontcho A.; Lesgourgues, Julien; Niro, Viviana; Pellejero-Ibanez, Marcos; Pérez Ràfols, Ignasi; Pulin, Vivian; Tram, Thomas; Tramonte, Denis; Verde, Licia (Data de publicació: 2017-02-16)

The existence of a cosmic neutrino background can be probed indirectly by CMB experiments, not only by measuring the background density of radiation in the universe, but also by searching for the typical signatures of the ...

Target enrichment metaviromics enables comprehensive surveillance of coronaviruses in environmental and animal samples 

Martínez-Puchol, Sandra; Tarradas-Alemany, Maria; Mejías-Molina, Cristina; Itarte, Marta; Rusiñol Arantegui, Marta; Baliellas, Jordi; Abasolo, Nerea; Canela, Núria; Monastiri, Abir; López-Roig, Marc; Serra Cobo, Jordi; Abril Ferrando, Josep Francesc, 1970-; Bofill Mas, Silvia (Data de publicació: 2024-11-19)

The COVID-19 pandemic has underscored the importance of understanding the role of animals in the transmission of coronaviruses (CoVs) and their impact on human health. A One Health approach, integrating human, animal, and ...

HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism 

Du, Weinan; Zhang, Luchang; Brett-Morris, Adina; Aguila, Brittany; Kerner, Janos; Hoppel, Charles L.; Puchowicz, Michelle; Serra i Cucurull, Dolors; Herrero Rodríguez, Laura; Rini, Brian I.; Campbell, Steven; Welford, Scott M. (Data de publicació: 2018-01-31)

Clear cell renal cell carcinoma (ccRCC) is histologically defined by its lipid and glycogen-rich cytoplasmic deposits. Alterations in the VHL tumor suppressor stabilizing the hypoxiainducible factors (HIFs) are the most ...

Biophysical approaches for drug discovery (Seminaris Tecnològics 2018) 

Galdeano Cantador, Carlos (Data de publicació: 2018-05-22)

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2 

Muñoz-Torrero López-Ibarra, Diego; Mangoni, Arduino A.; Liu, Hong; Hulme, Christopher; Rautio, Jarkko; Karaman, Rafik; Sousa, Maria Emília de; Prokai-Tatrai, Katalin; Sabatier, Jean-Marc; Siciliano, Carlo; Luque Garriga, F. Xavier; Kokotos, George; Ragno, Rino; Collina, Simona; Guillou, Catherine; Gütschow, Michael; Agrofoglio, Luigi A. (Data de publicació: 2018-04-19)

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials, which are published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the ...

Exploring the Phototherapeutic Applications of Mitochondria-Targeted COUPY Photocages of Antitumor Drugs 

López-Corrales, Marta; Izquierdo García, Eduardo; Bosch Marimon, Manel; Das, Tapas; Llebaria Soldevila, Amadeu; Josa-Culleré, Laia; Marchán Sancho, Vicente (Data de publicació: 2025-05-23)

Photocleavable protecting groups hold great promise in photopharmacology to control the release of bioactive molecules from their caged precursors within specific subcellular compartments. Herein, we describe a series of ...