Farmacologia, Toxicologia i Química Terapèutica: Recent submissions
Now showing items 81-100 of 675
Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring
A variety of environmental factors contribute significantly to age-related cognitive decline and memory impairment in Alzheimer's Disease (AD) and other neurodegenerative diseases. Nutrition can alter epigenetics, improving ...
Modulation and Protection Effects of Antioxidant Compounds against Oxidant Induced Developmental Toxicity in Zebrafish
The antioxidant effect of compounds is regularly evaluated by in vitro assays that do not have the capability to predict in vivo protective activity or to determine their underlying mechanisms of action. The aim of this ...
Translational Research and Drug Discovery for Neurodegeneration: Challenges for Latin America
Perhaps one of the most significant scientific challenges is to understand the human brain. Neuroscience research has had a considerable impact on individuals, families, and society. However, before we can have a real ...
Polysilicon Microchips Functionalized with Bipyridinium-Based Cyclophanes for a Highly Efficient Cytotoxicity in Cancerous Cells
The use of micrometric-sized vehicles could greatly improve selectivity of cytotoxic compounds as their lack of self-diffusion could maximize their retention in tissues. We have used polysilicon microparticles (SiμP) to ...
Cannabidiol Modulates the Motivational and Anxiety-Like Effects of 3,4-Methylenedioxypyrovalerone (MDPV) in Mice
: 3,4-Methylenedioxypyrovalerone (MDPV) is a new psychoactive substance (NPS) and the most widespread and life-threatening synthetic cathinone of the "bath salts". Preclinical research has proven the cocaine-like psychostimulant ...
Adipose Tissue Protects against Hepatic Steatosis in Male Rats Fed a High-Fat Diet plus Liquid Fructose: Sex-Related Differences
Non-alcoholic fatty liver disease is a sexual dimorphic disease, with adipose tissue playing an essential role. Our previous work showed that female rats fed a high-fat high-fructose diet devoid of cholesterol (HFHFr) ...
Heterocyclic betaines. XXII. Azinium(azolium) 4-nitrobenzimidazolate inner salts and their derivatives with several interannular spacers. Synthesis, characterization and antitrichomonal activity
The synthesis of an ensemble of pyridinium(imidazolium) 4-nitrobenzimidazolate bentaines and their derivatives with several interannular linkages has been explored. Their antiprotozoal activity has also been examined.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of editorials which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal ...
Inhibition of NMDA receptors through a membrane-to-channel path
N-methyl-D-aspartate receptors (NMDARs) are transmembrane proteins that are activated by the neurotransmitter glutamate and are found at most excitatory vertebrate synapses. NMDAR channel blockers, an antagonist class of ...
Stereocontrolled access to enantiopure to enantiopure 7-substituted cis- and trans-octahydroindoles
Cyclocondensation of (R)-phenylglycinol with stereoisomeric mixtures (racemates, cis/trans) of 3-substituted 2- oxocyclohexaneacetates stereoselectively afforded tricyclic oxazoloindolone lactams, from which straightforward ...
Triclabendazole sulfoxide causes stage-dependent embryolethality in zebrafish and mouse in vitro
Background Fascioliasis and paragonimiasis are widespread foodborne trematode diseases, affecting millions of people in more than 75 countries. The treatment of choice for these parasitic dis- eases is based on triclabendazole, ...
Synthesis of Alkaloids and Compounds Containing the 3,4-Benzomorphan Scaffold
Several natural products, bearing an embedded hexahydro-2,6-methano-1-benzazocine framework (3,4-benzomorphan) – a heterocyclic regioisomer of the 6,7-benzomorphan substructure found in morphine alkaloids, have therapeutic ...
A carboxylesterase, Esterase-6, modulates sensory physiological and behavioural response dynamics to pheromone in Drosophila
Background: Insects respond to the spatial and temporal dynamics of a pheromone plume, which implies not only a strong response to"odor on", but also to"odor off". This requires mechanisms geared toward a fast signal ...
Multicomponent reaction access to complex quinolines via oxidation of the povarov adducts
The tetrahydroquinolines obtained through the Povarov multicomponent reaction have been oxidized to the corresponding quinoline, giving access to a single product through a two-step sequence. Several oxidizing agents were ...
Effects of MDPV on dopamine transporter regulation in male rats. Comparison with cocaine.
RATIONALE: MDPV (3,4-methylenedioxypyrovalerone) is a synthetic cathinone present in bath salts. It is a powerful psychostimulant and blocker of the dopamine transporter (DAT), like cocaine. It is known that acute exposure ...
Liposomal formulations for waterproofing mucosal membranes
Liposome formulations consisting of lipids contained in the stratum corneum have been recently demonstrated to</p><p>decrease the permeability of mucosae. The permeability barrier of the mucosa is dependent on the presence ...
Environmental Enrichment Improves Cognitive Deficits, AD Hallmarks and Epigenetic Alterations Presented in 5xFAD Mouse Model.
Cumulative evidence shows that modifications in lifestyle factors constitute an effective strategy to modulate molecular events related to neurodegenerative diseases, confirming the relevant role of epigenetics. Accordingly, ...
Studies on the Interaction of Isocyanides with Imines: Reaction Scope and Mechanistic Variations
The interaction of imines with isocyanides has been studied. The main product results from a sequential process involving the attack of two units of isocyanide, under Lewis acid catalysis, upon the carbon-nitrogen double ...
