Bioquímica i Biomedicina Molecular: Envíos recientes
Mostrando ítems 61-80 de 917
Innovació: alerta roja
Les dades sobre l'Estat espanyol són dolentes, tant és així que, en referir-s'hi, la pàgina de resum titula: '«Aggravating decline: Spain»'. S'observa un descens de gairebé el 20% del pressupost públic en termes absoluts ...
NAD+-dependent post-translational modification of Escherichia coli glyceraldehyde-3-phosphate dehydrogenase
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional housekeeping protein reported to be a target of several covalent modifications in many organisms. In a previous study we showed that enterohemorragic ...
CD4 expression decrease by antisense oligonucleotides. Inhibition of rat T CD4+ cell reactivity
In previous studies, we have demonstrated the inhibition of CD4 expression in rat lymphocytes treated with phorbol myristate acetate (PMA) by antisense oligonucleotides (AS-ODNs) directed against the AUG start region of ...
La universitat híbrida
A final de novembre, la consultora IPSOS va dur a terme una enquesta per al World Economic Forum sobre com preveuen els enquestats que serà la universitat, presencial o telemàtica, d'aquí a cinc anys [...] Les respostes ...
Human endometrial CD98 is essential for blastocyst adhesion
Background Understanding the molecular basis of embryonic implantation is of great clinical and biological relevance. Little is currently known about the adhesion receptors that determine endometrial receptivity for embryonic ...
Stabilization of a prokaryotic LAT transporter by random mutagenesis
The knowledge of three-dimensional structures at atomic resolution of membrane transport proteins has improved considerably our understanding of their physiological roles and pathological implications. However, most ...
El drama de l'educació
La principal conclusió és que la possibilitat d'accés a la universitat està molt condicionada per l'origen social de l'estudiant. Concretament, conclouen que la probabilitat d'accedir a la universitat dels joves amb pares ...
Ghrelin and Cannabinoid Functional Interactions Mediated by Ghrelin/CB1 Receptor Heteromers That Are Upregulated in the Striatum From Offspring of Mice Under a High-Fat Diet
We have here assessed, using Δ9-tetrahydrocannabinol (Δ9-THC) for comparison, the effect of Δ9-tetrahydrocannabinolic acid (Δ9-THCA) and of Δ9-tetrahydrocannabivarin (Δ9-THCV) that is mediated by human versions of CB1, ...
El dèficit de R+D en el sector empresarial
Si ens fixem en la recerca bàsica, Catalunya és, sens dubte, líder a l'Estat. És el resultat d'una encertada tasca encetada a principi del decenni passat i que, malgrat les vicissituds pressupostàries negatives, s'ha ...
Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice
Parkin is an ubiquitin‐E3 ligase that is involved in cellular mitophagy and was recently shown to contribute to controlling adipose tissue thermogenic plasticity. We found that Parkin expression is induced in brown (BAT) ...
Erasmus i la recerca
Deixo ara el Regne Unit i m'ocupo del cas català. M'interessa especialment destacar que si en un moment o altre es formalitzés la independència de Catalunya i la creació d'un estat separat d'Espanya, no ens trobaríem als ...
Faced with a double challenge: obesity and climate change
The current global obesity epidemic is occurring in parallel with global warming due to climate change. Epidemiological evidence suggests a role for increasing environmental temperatures in increasing rates of overweight ...
D'ON VINDRAN LES PROTEÏNES?
Els sistemes alimentaris comprenen tots els elements i totes les activitats relacionades amb la producció, processament, distribució, preparació i consum d'aliments, i també els resultats d'aquestes activitats, incloent-hi ...
BioSWR - Semantic Web services Registry for Bioinformatics
Article About the Authors Metrics Comments Related Content Abstract Introduction Functionality Implementation Discussion Acknowledgments Author Contributions References Reader Comments (0) Figures Abstract Despite of the ...
Amyloid Beta Precursor Protein: Proper Credit for the Basic Biochemical Properties of the Most Studied Protein in the 21st Century
The amyloid precursor protein (APP) is mainly known for being the precursor of the ß-amyloid peptide, which accumulates in plaques found in the brain of Alzheimer's disease patients. Expression in different tissues and the ...
Bone Morphogenetic Protein-8B levels at birth and in the first year of life: relation to metabolic-endocrine variables and brown adipose tissue activity
Objective: Bone morphogenetic protein-8B (BMP8B) is an adipokine produced by brown adipose tissue (BAT) contributing to thermoregulation and metabolic homeostasis in rodent models. In humans, BAT activity is particularly ...
A Single Point Mutation Blocks the Entrance of Ligands to the Cannabinoid CB2 Receptor via the Lipid Bilayer
Molecular dynamic (MD) simulations have become a common tool to study the pathway of ligand entry to the orthosteric binding site of G protein-coupled receptors. Here, we have combined MD simulations and site-directed ...
The old and new visions of biased agonism through the prism of adenosine receptor signaling and receptor/receptor and receptor/protein interactions
Biased signaling is a concept that has arisen in the G protein-coupled receptor (GCPR) research field, and holds promise for the development of new drug development strategies. It consists of different signaling outputs ...
Molecular and functional interaction between GPR18 and cannabinoid CB2 G-protein-coupled receptors. Relevance in neurodegenerative diseases
GPR18, still considered an orphan receptor, may respond to endocannabinoids, whose canonical receptors are CB1 and CB2. GPR18 and CB2 receptors share a role in peripheral immune response regulation and are co-expressed in ...
Malonyl-CoA Mediates Leptin Hypothalamic Control of Feeding Independent of Inhibition of CPT-1a
Hypothalamic fatty acid metabolism is involved in central nervous system controls of feeding and energy balance. Malonyl-CoA, an intermediate of fatty acid biosynthesis, is emerging as a significant player in these processes. ...
