Bioquímica i Biomedicina Molecular: Enviaments recents
Ara mostrant els elements 41-60 de 917
Integrating systemic and molecular levels to infer key drivers sustaining metabolic adaptations
Metabolic adaptations to complex perturbations, like the response to pharmacological treatments in multifactorial diseases such as cancer, can be described through measurements of part of the fluxes and concentrations at ...
La universitat híbrida
A final de novembre, la consultora IPSOS va dur a terme una enquesta per al World Economic Forum sobre com preveuen els enquestats que serà la universitat, presencial o telemàtica, d'aquí a cinc anys [...] Les respostes ...
Microglial Adenosine Receptors: From Preconditioning to Modulating the M1/M2 Balance in Activated Cells
Neuronal survival depends on the glia, that is, on the astroglial and microglial support. Neurons die and microglia are activated not only in neurodegenerative diseases but also in physiological aging. Activated microglia, ...
KCNE4-dependent functional consequences of Kv1.3-related leukocyte physiology.
The voltage-dependent potassium channel Kv1.3 plays essential roles in the immune system, participating in leukocyte activation, proliferation and apoptosis. The regulatory subunit KCNE4 acts as an ancillary peptide of ...
Professorat en la misèria
La figura s'ha prostituït i a Catalunya el professorat associat és d'unes 6.000 persones amb antiguitat diversa i dedicació variable (no compto el professorat associat mèdic de característiques diferents). El professorat ...
Caveolin interaction governs Kv1.3 lipid raft targeting
The spatial localization of ion channels at the cell surface is crucial for their functional role. Many channels localize in lipid raft microdomains, which are enriched in cholesterol and sphingolipids. Caveolae, specific ...
Suppression of glycogen synthesis as a treatment for Lafora disease: Establishing the window of opportunity
Lafora disease (LD) is a fatal adolescence-onset neurodegenerative condition. The hallmark of LD is the accumulation of aberrant glycogen aggregates called Lafora bodies (LBs) in the brain and other tissues. Impeding ...
Epigenetic loss of the endoplasmic reticulum-associated degradation inhibitor SVIP induces cancer cell metabolic reprogramming
The endoplasmic reticulum (ER) of cancer cells needs to adapt to the enhanced proteotoxic stress associated with the accumulation of unfolded, misfolded and transformation-associated proteins. One way by which tumors thrive ...
The physicochemical, biopharmaceutical, and in vitro efficacy properties of freeze-dried dexamethasone-loaded lipomers.
Dexamethasone-loaded polymer hybrid nanoparticles were developed as a potential tool to treat alopecia areata due to their follicular targeting ability. Freeze drying (FD) is a common technique used to improve nanoparticle ...
Equilibrative Nucleoside Transporter ENT1 as a Biomarker of Huntington Disease
The initial goal of this study was to investigate alterations in adenosine A2A receptor (A2AR) density or function in a rat model of Huntington disease (HD) with reported insensitivity to an A2AR antagonist. Unsuspected ...
Les diferències entre Escòcia i Catalunya en educació
Tot i que Catalunya és atractiva per fer-hi estudis superiors, només atraurem estudiants per la qualitat de les nostres universitats i per l'atractiu i la geografia de Barcelona. Si comparem les universitats de Catalunya ...
Increased Circulating Levels of Growth Differentiation Factor 15 in Association with Metabolic Disorders in People Living with HIV Receiving Combined Antiretroviral Therapy
Objective: People living with HIV (PLWH) have an increased cardiovascular risk (CVR) owing to dyslipidemia, insulin resistance, metabolic syndrome, and HIV/combination antiretroviral therapy (cART)-associated lipodystrophy ...
Reversible photocontrol of dopaminergic transmission in wild-type animals
Understanding the dopaminergic system is a priority in neurobiology and neuropharmacology. Dopamine receptors are involved in the modulation of fundamental physiological functions and dysregulation of dopaminergic transmission ...
Advancing Personalized Medicine by Analytical Means: Selection of Three Metabolites That Allows Discrimination between Glaucoma, Diabetes, and Controls
This paper aimed at devising an intelligence-based method to select compounds that can distinguish between open-angle glaucoma patients, type 2 diabetes patients, and healthy controls. Taking the concentration of 188 ...
Evaluation of macrophage plasticity in brown and white adipose tissue
There are still questions about whether macrophage differentiation is predetermined or is induced in response to tissue microenvironments. C2D macrophage cells reside early in the macrophage lineage in vitro, but differentiate ...
Stochastic modulation evidences a transitory EGF-Ras-ERK MAPK activity induced by PRMT5
The extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) pathway involves a three-step cascade of kinases that transduce signals and promote processes such as cell growth, development, and ...
Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosis
Background: Metabolic flux profiling based on the analysis of distribution of stable isotope tracer in metabolites is an important method widely used in cancer research to understand the regulation of cell metabolism and ...
Estalviar en R+D+I surt car
A Catalunya parlar d'innovació s'ha convertit gairebé en un tòpic. Sentim en declaracions i discursos que la R+D+I hauria de salvar l'economia del país, però, realment, quants dels que ho diuen s'ho creuen? No ho sé, però ...
La universitat del futur estat català
Que és una Universitat millor? Estaríem d'acord que una universitat millor que l'actual seria una Universitat que proporcionés docència de més qualitat, amb la recerca més reconeguda internacionalment i que dels seus ...
