Bioquímica i Biomedicina Molecular: Envíos recientes
Mostrando ítems 81-100 de 917
Molecular simulations meet personalized medicine: The mechanism of action of CLC-5 antiporter and the origin of Dent's disease
ClC-5 is a Cl-/H+ antiporter crucial for the homeostasis of the entire organism, and whose functional deficiencies cause pathologies such as Dent's disease, a rare genetic disorder that can have lethal consequences. ...
From Current Therapeutics to Multitarget Ligands: A Review of Diabetes Pharmacological Treatments
Diabetes is a chronic and complex pathological syndrome that includes a series of disorders and imbalances, whose first characterization is hyperglycemia, although, as it is a multifactorial phenomenon, it requires risk ...
RNase H-sensitive multifunctional ASO-based constructs as promising tools for the treatment of multifactorial complex pathologies
Combined therapies play a key role in the fight against complex pathologies, such as cancer and related drug-resistance issues. This is particularly relevant in targeted therapies where inhibition of the drug target can ...
Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain
Caffeine, the most widely consumed psychoactive substance in the world, is used to promote wakefulness and enhance alertness. Like other wake-promoting drugs (stimulants and modafinil), caffeine enhances dopamine (DA) ...
Characterization of two membrane-associated β-glucosidases from maize coleoptiles
We isolated membrane vesicles from maize (Zea mays L.) coleoptiles and identified in these vesicles a 58 kDa (pm58) and a 60 kDa (pm60) protein by photoaffinity labelling with 5-azido-[7-3H]indole-3-acetic acid ([3H]N3IAA). ...
Nucleotide sequence of a rice cDNA encoding a transkelotase-like protein homologous to the Arabidopsis CLA1gene product (Accession No. AF024512) (PGR 97-169)
The Arabidopsis gene CLA1 is required for normal chloroplast development. Disruption of this gene has a recessive pleiotropic effect consisting on arrest of chloroplast development at an early stage, reduction of the ...
The use of an alternative promoter in the Arabidopsis thaliana HMG1 gene generates an mRNA that encodes a novel 3-hydroxy-3-methylglutaryl Coenzyme A reductase isoform with an extended N-terminal region
The enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR, EC 1.1.1.34) catalyses the synthesis of mevalonate, the committed precursor of the great variety of isoprenoid compounds and derivatives synthesized in higher ...
1-Deoxy-D-xylulose 5-phosphate reductoisomerase and plastid isoprenoid biosynthesis during tomato fruit ripening
The recently discovered 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for the biosynthesis of plastid isoprenoids (including carotenoids) is not fully elucidated yet despite its central importance for plant life. It ...
α<sub>2A</sub>- and α<sub>2C</sub>-Adrenoceptors as significant targets for dopamine and dopamine receptor ligands
The poor norepinephrine innervation and high density ofGi/o-coupled α2A- andα2C-adrenoceptors in the striatum and the dense striatal dopamine innervation have prompted the possibility that dopamine could be an effective ...
Arabidopsis thaliana expresses two functional isoforms of Avrp, a protein involved in the regulation of cellular lipid homeostasis
Arv1p is involved in the regulation of cellular lipid homeostasis in the yeast Saccharomyces cerevisiae. Here, we report the characterization of the two Arabidopsis thaliana ARV genes and the encoded proteins, AtArv1p and ...
Incorporation of [2,3-13C2]- and [2,4-13C 2]-D-1-deoxyxululose into ubiquinone of Escherichia coli via the mevalonate-independent pathway for isoprenoid biosynthesis
[2,3-13C2]- and [2,4-13C2]-d-1-deoxyxylulose were synthesized from [2-13C]pyruvate and [1-13C]- or [2-13C]-dl-glyceraldehyde using the enzyme d-1-deoxyxylulose 5-phosphate synthase from Escherichia coli which was overexpressed ...
Mevalonate biosynthesis in plants
The enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR, R-mevalonate: NADP+ oxidoreductase, CoA-acylating, EC 1.1.1.34) catalyzes the reductive conversion of HMG-CoA to mevalonic acid (MVA). This reaction ...
CD4 expression decrease by antisense oligonucleotides. Inhibition of rat T CD4+ cell reactivity
In previous studies, we have demonstrated the inhibition of CD4 expression in rat lymphocytes treated with phorbol myristate acetate (PMA) by antisense oligonucleotides (AS-ODNs) directed against the AUG start region of ...
La universitat híbrida
A final de novembre, la consultora IPSOS va dur a terme una enquesta per al World Economic Forum sobre com preveuen els enquestats que serà la universitat, presencial o telemàtica, d'aquí a cinc anys [...] Les respostes ...
Human endometrial CD98 is essential for blastocyst adhesion
Background Understanding the molecular basis of embryonic implantation is of great clinical and biological relevance. Little is currently known about the adhesion receptors that determine endometrial receptivity for embryonic ...
Stabilization of a prokaryotic LAT transporter by random mutagenesis
The knowledge of three-dimensional structures at atomic resolution of membrane transport proteins has improved considerably our understanding of their physiological roles and pathological implications. However, most ...
El drama de l'educació
La principal conclusió és que la possibilitat d'accés a la universitat està molt condicionada per l'origen social de l'estudiant. Concretament, conclouen que la probabilitat d'accedir a la universitat dels joves amb pares ...
Ghrelin and Cannabinoid Functional Interactions Mediated by Ghrelin/CB1 Receptor Heteromers That Are Upregulated in the Striatum From Offspring of Mice Under a High-Fat Diet
We have here assessed, using Δ9-tetrahydrocannabinol (Δ9-THC) for comparison, the effect of Δ9-tetrahydrocannabinolic acid (Δ9-THCA) and of Δ9-tetrahydrocannabivarin (Δ9-THCV) that is mediated by human versions of CB1, ...
Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis
A combination of molecular modeling and structure activity relationship studies has been used to fine-tune CB2 selectivity in the chromenopyrazole ring, a versatile CB1/CB2 cannabinoid scaffold. Thus, a series of 36 new ...
El dèficit de R+D en el sector empresarial
Si ens fixem en la recerca bàsica, Catalunya és, sens dubte, líder a l'Estat. És el resultat d'una encertada tasca encetada a principi del decenni passat i que, malgrat les vicissituds pressupostàries negatives, s'ha ...
