Bioquímica i Biomedicina Molecular: Envíos recientes
Mostrando ítems 101-120 de 918
Cocaine blocks effects of hunger hormone, ghrelin, via interaction with neuronal sigma-1 receptors.
Despite ancient knowledge on cocaine appetite-suppressant action, the molecular basis of such fact remains unknown. Addiction/eating disorders (e.g., binge eating, anorexia, bulimia) share a central control involving reward ...
Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain
BACKGROUND: G-protein-coupled receptor (GPCR) heteromeric complexes have distinct properties from homomeric GPCRs, giving rise to new receptor functionalities. Adenosine receptors (A1R or A2AR) can form A1R-A2AR heteromers ...
Neuronal calcium and cAMP cross-talk mediated by cannabinoid CB1 receptor and EF-hand calcium sensor interactions.
Endocannabinoids are important players in neural development and function. They act via receptors, whose activation inhibits cAMP production. The aim of the paper was to look for calcium- and cAMP-signaling cross-talk ...
Nitric oxide and the release of lipoprotein lipase from white adipose tissue
Background/Aim: Lipoprotein lipase (LPL) is the main enzyme responsible for the distribution of circulating triacylglycerides in tissues. Its regulation via release from active sites in the vascular endothelium is poorly ...
Cancer-Associated Fibroblasts in breast cancer treatment response and metastasis.
Breast cancer (BrCa) is the leading cause of death among women worldwide, with about one million new cases diagnosed each year. In spite of the improvements in diagnosis, early detection and treatment, there is still a ...
Voltage-dependent Na+ channel phenotype changes in myoblasts. Consequences for cardiac repair
Objective: Cellular cardiomyoplasty using skeletal myoblasts is a promising therapy for myocardial infarct repair. Once transplanted, myoblasts grow, differentiate and adapt their electrophysiological properties towards ...
Antioxidant Activity and Neuroprotective Role of Docosahexaenoic Acid (DHA) Supplementation in Eye Diseases That Can Lead to Blindness: A Narrative Review
Nowadays, more and more young people want to experience illegal, psychoactive substances, without knowing the risks of exposure. Besides affecting social life, psychoactive substances also have an important effect on ...
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CBL/CAP is essential for mitochondria respiration complex I assembly and bioenergetics efficiency in muscle cells.
CBL is rapidly phosphorylated upon insulin receptor activation. Mice whole body CBL depletion improved insulin sensitivity and glucose clearance, however, the precise mechanisms remain unknown. We depleted either CBL or ...
Calorie restriction improves physical performance and modulates the antioxidant and inflammatory responses to acute exercise
Our aim was to characterize the effects of calorie restriction on the anthropometric characteristics and physical performance of sportsmen and to evaluate the effects of calorie restriction and acute exercise on mitochondria ...
Challenges and guidelines toward 4D nucleome data and model standards
Due to recent advances in experimental and theoretical approaches, the dynamic three-dimensional organization (3D) of the nucleus has become a very active area of research in life sciences. We now understand that the linear ...
Molecular dynamics study of natural existing cavity couplings in proteins
Couplings between protein sub-structures are a common property of protein dynamics. Some of these couplings are especially interesting since they relate to function and its regu- lation. In this article we have studied the ...
Residues coevolution guides the systematic identification of alternative functional conformations in proteins
We present here a new approach for the systematic identification of functionally relevant conformations in proteins. Our fully automated pipeline, based on discrete molecular dynamics enriched with coevolutionary information, ...
Prediction and validation of protein intermediate states from structurally rich ensembles and coarse grained simulations
Protein conformational changes are at the heart of cell functions, from signalling to ion transport. However, the transient nature of the intermediates along transition pathways hampers their experimental detection, making ...
Bioactive conformational ensemble server and database. A public framework to speed up in silico drug discovery.
Modern high-throughput structure-based drug discovery algorithms consider ligand flexibility, but typically with low accuracy, which results in a loss of performance in the derived models. Here we present the Bioactive ...
Small Details Matter: The 2'-Hydroxyl as a Conformational Switch in RNA
While DNA is mostly a primary carrier of genetic information and displays a regular duplex structure, RNA can form very complicated and conserved 3D structures displaying a large variety of functions, such as being an ...
Parmbsc1: A refined force-field for DNA simulations
We present parmbsc1, a force field for DNA atomistic simulation, which has been parameterized from high-level quantum mechanical data and tested for nearly 100 systems (representing a total simulation time of ∼140 μs) ...
Regulation of death receptor signaling by the autophagy protein TP53INP2
TP53INP2 positively regulates autophagy by binding to Atg8 proteins. Here, we uncover a novel role of TP53INP2 in death‐receptor signaling. TP53INP2 sensitizes cells to apoptosis induced by death receptor ligands. In keeping ...
Difining the Nature of Thermal Intermediate in 3 State Folding Proteins: Apoflavodoxin, a Study Case
The early stages of the thermal unfolding of apoflavodoxin have been determined by using atomistic multi microsecond-scale molecular dynamics (MD) simulations complemented with a variety of experimental techniques. Results ...
