Bioquímica i Biomedicina Molecular: Enviaments recents
Ara mostrant els elements 121-140 de 918
CGeNArate: a sequence-dependent coarse-grained model of DNA for accurate atomistic MD simulations of kb-long duplexes
We present CGeNArate, a new model for molecular dynamics simulations of very long segments of B-DNA in the context of biotechnological or chromatin studies. The developed method uses a coarse-grained Hamiltonian with ...
Expression of Glycogen Phosphorylase Isoforms in Cultured Muscle from Patients with McArdle´s Disease Carrying the p.R771PfsX33 PYGM Mutation
Mutations in the PYGM gene encoding skeletal muscle glycogen phosphorylase (GP) cause a metabolic disorder known as McArdle's disease. Previous studies in muscle biopsies and cultured muscle cells from McArdle patients ...
uPAR-controlled oncolytic adenoviruses eliminate cancer stem cells in human pancreatic tumors
Abstract Pancreatic tumors contain cancer stem cells highly resistant to chemotherapy. The identification of therapies that can eliminate this population of cells might provide with more effective treatments. In the current ...
D816V KIT mutation induces mitochondrial morphologic and functional changes through BNIP3 downregulation in human myeloid cell lines ROSA and TF-1
The KIT receptor is a transmembrane protein found on the surface of many different cell types. Mutant forms of KIT are drivers of myeloid neoplasms, including systemic mastocytosis. The KIT D816V mutation is the most common, ...
Cornelia de Lange syndrome with NIBPL mutation and mosaic Turner syndrome in the same individual
Background: Cornelia de Lange syndrome (CdLS) is a dominantly inherited disorder characterized by facial dysmorphism, growth and cognitive impairment, limb malformations and multiple organ involvement. Mutations in NIPBL ...
Insulin signalling regulates fatty acid catabolisme at the level of CoA activation
The insulin/IGF signaling pathway is a highly conserved regulator of metabolism in flies and mammals, regulating multiple physiological functions including lipid metabolism. Although insulin signaling is known to regulate ...
In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancer
Constraint-based modeling for genome-scale metabolic networks has emerged in the last years as a promising approach to elucidate drug targets in cancer. Beyond the canonical biosynthetic routes to produce biomass, it is ...
R+D+i, la clau de l'estat del benestar
Els indicadors que mesuren la situació de la nostra recerca bàsica no són dolents. Les publicacions i llur impacte en la comunitat científica internacional certifiquen una posició digna d'universitats, centres de recerca ...
Health benefits of methylxanthines in cacao and chocolate
One may wonder why methylxanthines are so abundant in beverages used by humans for centuries, or in cola-drinks that have been heavily consumed since their appearance. It is likely that humans have stuck to any brew ...
Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors
Antagonistic and reciprocal interactions are known to exist between adenosine and dopamine receptors in the striatum. In the present study, double immunofluorescence experiments with confocal laser microscopy showed a high ...
Eighty years of targeting androgen receptor activity in prostate cancer: the fight goes on
Prostate cancer (PCa) is the most common cancer in men in the West, other than skin cancer, accounting for over a quarter of cancer diagnoses in US men. In a seminal paper from 1941, Huggins and Hodges demonstrated that ...
Sex-Dependent Metabolic Effects in Diet-Induced Obese Rats following Intermittent Fasting Compared with Continuous Food Restriction
Recently, intermittent fasting has gained relevance as a strategy to lose weight and improve health as an alternative to continuous caloric restriction. However, the metabolic impact and the sex-related differences are not ...
Dual role of LldR in regulation of the lldPRD operon, involved in l-Lactate metabolism in Escherichia coli.
The lldPRD operon of Escherichia coli, involved in L-lactate metabolism, is induced by growth in this compound. We experimentally identified that this system is transcribed from a single promoter with an initiation site ...
The SUD1 Gene Encodes a Putative E3 Ubiquitin Ligase and Is a Positive Regulator of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Arabidopsis
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme catalyzes the major rate-limiting step of the mevalonic acid (MVA) pathway from which sterols and other isoprenoids are synthesized. In contrast with our extensive ...
Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope
Epidermal growth factor receptor (EGFR) signaling is initiated by a large ligand-favored conformational change of the extracellular domain (ECD) from a closed, self-inhibited tethered monomer, to an open untethered state, ...
L'evolució de la universitat
No discuteixo si l'educació d'ara ajuda més a tenir millors i més ben preparats ciutadans que la d'abans o no, però sí que els alumnes d'abans arribaven a la universitat amb més coneixements de matemàtiques, de química, ...
Biased receptor functionality versus biased agonism in G-protein-coupled receptors
Functional selectivity is a property of G-protein-coupled receptors (GPCRs) by which activation by different agonists leads to different signal transduction mechanisms. This phenomenon is also known as biased agonism and ...
Allosteric conversation in the androgen receptor ligand-binding domain surfaces
Androgen receptor (AR) is a major therapeutic target that plays pivotal roles in prostate cancer (PCa) and androgen insensitivity syndromes. We previously proposed that compounds recruited to ligand-binding domain (LBD) ...
Temes de bioquímica : treballs de recerca
El Departament de Bioquímica i Biologia Molecular de la Universitat de Barcelona, dintre de la seva línia de col·laboració amb els centres de Ssecundària, ha desenvolupat aquesta guia sobre treballs de recerca a secundària ...
Unveiling the Metabolic changes on muscle cell metabolism underlying p-phenylenediamine toxicity
Rhabdomyolysis is a disorder characterized by acute damage of the sarcolemma of the skeletal muscle leading to release of potentially toxic muscle cell components into the circulation, most notably creatine phosphokinase ...
