Bioquímica i Biomedicina Molecular: Envíos recientes
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La formació superior enfocada a l'ocupació
Fa temps que defenso que caldria una profunda revisió i una anàlisi 'a posteriori' que correlacioni estudis fets i ocupació al cap dels anys. L'Agència per a la Qualitat del Sistema Universitari de Catalunya (AQU) ens està ...
Does Dietary Coenzyme Q10 plus Selenium Supplementation Ameliorate Clinical Outcomes by Modulating Oxidative Stress and Inflammation in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a neuroinflammatory, multifaceted chronic disorder of unknown cause. Accumulating data indicate a link between a redox imbalance, mitochondrial dys-function, ...
Determination of a structural ensemble representing the dynamics of a G-Quadruplex DNA
It is increasingly recognized that the structures and dynamics of G-quadruplex DNA molecules are dictated by their sequences and greatly affected by environmental factors. The core guanine tetrads (G-tetrads) coordinate ...
Past, present and future of A(2A) adenosine receptor antagonists in the therapy of Parkinson's disease
Several selective antagonists for adenosine A2A receptors (A2AR) are currently under evaluation in clinical trials (phases I to III) to treat Parkinson's disease, and they will probably soon reach the market. The usefulness ...
Exercise Reduces the Resumption of Tumor Growth and Proteolytic Pathways in the Skeletal Muscle of Mice Following Chemotherapy
The pathogenesis of muscle atrophy plays a central role in cancer cachexia, and chemotherapy contributes to this condition. Therefore, the present study aimed to evaluate the effects of endurance exercise on time-dependent ...
The MEF2A isoform is required for striated muscle-specific expression of the insulin-responsive Glut4 glucose transporter
Previously, we have demonstrated that an MEF2 consensus sequence located between −473/−464 in the human GLUT4 gene was essential for both tissue-specific and hormonal/metabolic regulation of GLUT4 expression (Thai, M. V., ...
Neuregulin signaling on glucose transport in muscle cells
Neuregulin-1, a growth factor that potentiates myogenesis induces glucose transport through translocation of glucose transporters, in an additive manner to insulin, in muscle cells. In this study, we examined the signaling ...
Shivering unlocks new way of fighting fat
Shivering is not an activity many of us enjoy. We do it because we are cold and uncomfortable. But perhaps the news that it could have some of the same benefits as moderate bouts of exercise will stop us running in from ...
The Mitochondrial Routing of the Kv1.3 Channel
Voltage-gated potassium channels control neuronal excitability and cardiac action potentials. In addition, these proteins are involved in a myriad of cellular processes. The potassium channel Kv1.3 plays an essential role ...
Reduced adenosine uptake and its contribution to signaling that mediates profibrotic activation in renal tubular epithelial cells: implication in diabetic nephropathy.
Altered nucleoside levels may be linked to pathogenic signaling through adenosine recep- tors. We hypothesized that adenosine dysregulation contributes to fibrosis in diabetic kid- ney disease. Our findings indicate that ...
Differential effects of dolutegravir, bictegravir and raltegravir in adipokines and inflammation markers on human adipocytes.
Aims: To assess the potential direct effects of the integrase strand-transfer inhibitors (INsTIs) dolutegravir, bictegravir, and raltegravir, drugs used as treatment for people living with human immunodeficiency virus ...
Precursor uptake assays and metabolic analyses in isolated tomato fruit chromoplasts
Background Carotenoids are the most widespread group of pigments found in nature. In addition to their role in the physiology of the plant, carotenoids also have nutritional relevance as their incorporation in the human ...
Cardiovascular disease-related parameters and Oxidative stress in SHROB rats, a model for metabolic syndrome.
SHROB rats have been suggested as a model for metabolic syndrome (MetS) as a situation prior to the onset of CVD or type-2 diabetes, but information on descriptive biochemical parameters for this model is limited. Here, ...
Maternal imprinting on cognition markers of wild type and transgenic Alzheimer's disease model mice.
The risk of suffering from Alzheimer's disease (AD) is higher in individuals from AD-affected mothers. The purpose of this investigation was to study whether maternal transmission might produce AD-related alterations in ...
Functional characterization of the alanine-serine-cysteine exchanger of Carnobacterium sp AT7
Many key cell processes require prior cell uptake of amino acids from the environment, which is facilitated by cell membrane amino acid transporters such as those of the L-type amino acid transporter (LAT) subfamily. ...
A novel mitochondrial Kv1.3-caveolin axis controls cell survival and apoptosis
The voltage-gated potassium channel Kv1.3 plays an apparent dual physiological role by participating in activation and proliferation of leukocytes as well as promoting apoptosis in several types of tumor cells. Therefore, ...
Allostatic hypermetabolic response in PGC1α/β heterozygote mouse despite mitochondrial defects
Aging, obesity, and insulin resistance are associated with low levels of PGC1α and PGC1β coactivators and defective mitochondrial function. We studied mice deficient for PGC1α and PGC1β [double heterozygous (DH)] to ...
Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.
The ability to regulate specific genes of energy metabolism in response to fasting and feeding is an important adaptation allowing survival of intermittent food supplies. However, little is known about transcription factors ...
Lipid raft microdomain compartalization of TC10 is required for insulin signalling and Glut4 Translocation
Recent studies indicate that insulin stimulation of glucose transporter (GLUT)4 translocation requires at least two distinct insulin receptor-mediated signals: one leading to the activation of phosphatidylinositol 3 (PI-3) ...
Inflammation and Obesity (Lipoinflammation)
Obesity is a chronic disease with multiple origins. It is a widespread global phenomenon carrying potentially serious complications which requires a multidisciplinary approach due to the significant clinical repercussions ...
