The Drinking Motives Questionnaire-Revised (DMQ-R; Cooper, 1994) is the most widely used questionnaire to assess drinking motives. This research aimed to adapt and study the validity and reliability of the Spanish DMQ-R and its short form in a sample of adolescents. We assessed 504 drinkers at Time 1 (T1, Mage = 14.15, SD = 0.60, 52.38% female), of whom 238 participated in a 1-year follow-up (T2, Mage = 15.05, SD = 0.54, 58.82% female). They completed the DMQ-R at T1, the alcohol use measure at T1 and T2, and the alcohol-related problems questionnaire at T2. We performed Confirmatory Factor Analyses (CFAs) to test the structure validity of the questionnaire, Cronbach's alphas to test the internal consistencies of the scales, and path analyses to test the concurrent and predictive validity of motives on alcohol outcomes. CFA indicated that the short form of the 4-factor model best fitted the data. Cronbach's alphas were .70 or higher. Direct effects of the path analysis showed that social motives cross-sectionally predicted alcohol use, while coping motives prospectively predicted alcohol-related problems. Indirect effects showed that social motives prospectively predicted alcohol use and problems. To conclude, the DMQ-R short form appears to be reliable and valid to assess drinking motives among Spanish adolescents.