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Early adversity and 5-HTT-BDNF genes:  New evidences of Gene-Environment interactions on depressive symptoms in a general population
Aguilera, María del Carmen; Arias Sampériz, Bárbara; Wichers, Marieke; Barrantes Vidal, Neus; Moya Higueras, Jorge; Villa Martín, Helena; Os, J. van (Jim van); Ibáñez Ribes, Manuel Ignacio; Ruipérez Rodríguez, María Ángeles; Ortet i Fabregat, Generós; Fañanás Saura, Lourdes
Universitat de Barcelona
Background Adverse childhood experiences have been described as one of the major environmental risk factors for depressive disorder. Similarly, the deleterious impact of early traumatic experiences on depression seems to be moderated by individual genetic variability. Serotonin transporter (5-HTT) and brain-derived neurotrophic factor (BDNF) modulate the effect of childhood adversity on adult depression, although inconsistencies across studies have been found. Moreover, the gene×environment (G×E) interaction concerning the different types of childhood adversity remains poorly understood. The aim of this study was to analyse the putative interaction between the 5-HTT gene (5-HTTLPR polymorphism), the BDNF gene (Val66Met polymorphism) and childhood adversity in accounting for adult depressive symptoms. Method A sample of 534 healthy individuals filled in self-report questionnaires of depressive symptomatology [the Symptom Check List 90 Revised (SCL-90-R)] and different types of childhood adversities [the Childhood Trauma Questionnaire (CTQ)]. The 5-HTTLPR polymorphism (5-HTT gene) and the Val66Met polymorphism (BDNF gene) were genotyped in the whole sample. Results Total childhood adversity (β=0.27, p<0.001), childhood sexual abuse (CSA; β=0.17, p<0.001), childhood emotional abuse (β=0.27, p<0.001) and childhood emotional neglect (β=0.22, p<0.001) had an impact on adult depressive symptoms. CSA had a greater impact on depressive symptoms in Met allele carriers of the BDNF gene than in the Val/Val group (F=5.87, p<0.0001), and in S carriers of the 5-HTTLPR polymorphism (5-HTT gene) (F=5.80, p<0.0001). Conclusions Childhood adversity per se predicted higher levels of adult depressive symptoms. In addition, BDNF Val66Met and 5-HTTLPR polymorphisms seemed to moderate the effect of CSA on adult depressive symptoms.
Depressió psíquica
Gens
Psicopatologia
Serotonina
Depressió psíquica en els infants
Medi ambient
Població
Mental depression
Genes
Pathological psychology
Serotonin
Depression in children
Environment
Population
(c) Cambridge University Press, 2009
Article
info:eu-repo/semantics/publishedVersion
Cambridge University Press
         

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