Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/107940

Systematic analysis of the polyphenol metabolome using the Phenol-Explorer database
Rothwell, Joseph A.; Urpí Sardà, Mireia; Boto Ordóñez, María; Llorach, Rafael; Farran, Andreu; Barupal, Dinesh Kumar; Neveu, Vanessa; Manach, Claudine; Andrés Lacueva, Ma. Cristina; Scalbert, Augustin
Universitat de Barcelona
SCOPE: The Phenol-Explorer web database details 383 polyphenol metabolites identified in human and animal biofluids from 221 publications. Here we exploit these data to characterize and visualize the polyphenol metabolome, the set of all metabolites derived from phenolic food components. METHODS AND RESULTS: Qualitative and quantitative data on 383 polyphenol metabolites as described in 424 human and animal intervention studies were systematically analyzed. Of these metabolites, 301 were identified without prior enzymatic hydrolysis of biofluids, and included glucuronide and sulfate esters, glycosides, aglycones, and O-methyl ethers. Around one third of these compounds are also known as food constituents and corresponded to polyphenols absorbed without further metabolism. Many ring-cleavage metabolites formed by gut microbiota were noted, mostly derived from hydroxycinnamates, flavanols and flavonols. Median maximum plasma concentrations (Cmax ) of all human metabolites were 0.09 μM and 0.32 μM when consumed from foods or dietary supplements respectively. Median time to reach maximum plasma concentration in humans (Tmax ) was 2.18 h. CONCLUSION: These data show the complexity of the polyphenol metabolome and the need to take into account biotransformations to understand in vivo bioactivities and the role of dietary polyphenols in health and disease. This article is protected by copyright. All rights reserved.
Biodisponibilitat
Metabolisme
Farmacocinètica
Polifenols
Metabòlits
Consum d'aliments
Bioavailability
Metabolism
Pharmacokinetics
Polyphenols
Metabolites
Food consumption
cc-by (c) Rothwell, Joseph A. et al., 2015
http://creativecommons.org/licenses/by/3.0/es
Artículo
info:eu-repo/semantics/publishedVersion
Wiley-VCH
         

Mostrar el registro completo del ítem

Documentos relacionados

Otros documentos del mismo autor/a

Rothwell, Joseph A.; Urpí Sardà, Mireia; Boto Ordóñez, María; Knox, Craig; Llorach, Rafael; Eisner, Roman; Cruz, Joseph; Neveu, Vanessa; Wishart, David S.; Manach, Claudine; Andrés Lacueva, Ma. Cristina; Scalbert, Augustin
Rothwell, Joseph A.; Perez-Jimenez, Jara; Neveu, Vanessa; Medina Remón, Alexander; M'Hiri, Nouha; García-Lobato, Paula; Manach, Claudine; Knox, Craig; Eisner, Roman; Wishart, David S.; Scalbert, Augustin
Gao, Qian; Praticò, Giulia; Scalbert, Augustin; Vergères, Guy; Kolehmainen, Marjukka; Manach, Claudine; Brennan, Lorraine; Afman, Lydia A.; Wishart, David S.; Andrés Lacueva, Ma. Cristina; Garcia Aloy, Mar; Verhagen, Hans; Feskens, Edith J.M.; Dragsted, Lars O.
Boto Ordóñez, María; Urpí Sardà, Mireia; Queipo-Ortuño, María Isabel; Tulipani, Sara; Tinahones, Francisco J.; Andrés Lacueva, Ma. Cristina
Urpí Sardà, Mireia; Boto Ordóñez, María; Queipo-Ortuño, María Isabel; Tulipani, Sara; Corella, Dolores; Estruch Riba, Ramon; Tinahones, Francisco J.; Andrés Lacueva, Ma. Cristina