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Mechanisms underlying cytotoxicity induced by engineered nanomaterials: a review of in vitro studies
Nogueira, Daniele R.; Mitjans Arnal, Montserrat; Rolim, Clarice M.B.; Vinardell Martínez-Hidalgo, Ma. Pilar
Universitat de Barcelona
Engineered nanomaterials are emerging functional materials with technologically interesting properties and a wide range of promising applications, such as drug delivery devices, medical imaging and diagnostics, and various other industrial products. However, concerns have been expressed about the risks of such materials and whether they can cause adverse effects. Studies of the potential hazards of nanomaterials have been widely performed using cell models and a range of in vitro approaches. In the present review, we provide a comprehensive and critical literature overview on current in vitro toxicity test methods that have been applied to determine the mechanisms underlying the cytotoxic effects induced by the nanostructures. The small size, surface charge, hydrophobicity and high adsorption capacity of nanomaterial allow for specific interactions within cell membrane and subcellular organelles, which in turn could lead to cytotoxicity through a range of different mechanisms. Finally, aggregating the given information on the relationships of nanomaterial cytotoxic responses with an understanding of its structure and physicochemical properties may promote the design of biologically safe nanostructures.
Cultiu cel·lular
Nanotoxicologia
Cell culture
Nanotoxicology
cc-by (c) Nogueira, Daniele R. et al., 2014
http://creativecommons.org/licenses/by/3.0/es
Article
info:eu-repo/semantics/publishedVersion
MDPI Publishing
         

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Scheeren, Laís E.; Nogueira, Daniele R.; Macedo, Letícia B.; Vinardell Martínez-Hidalgo, Ma. Pilar; Mitjans Arnal, Montserrat; Infante Martínez-Pardo, Ma. Rosa; Rolim, Clarice M.B.
Nogueira, Daniele R.; Scheeren, Laís E.; Vinardell Martínez-Hidalgo, Ma. Pilar; Mitjans Arnal, Montserrat; Infante Martínez-Pardo, Ma. Rosa; Rolim, Clarice M.B.
Nogueira, Daniele R.; Scheeren, Laís E.; Macedo, Letícia B.; Marcolino, Ana Isa P.; Mitjans Arnal, Montserrat; Vinardell Martínez-Hidalgo, Ma. Pilar; Infante Martínez-Pardo, Ma. Rosa; Farooqi, Ammad A.; Rolim, Clarice M.B.
Nogueira D.R.; Macedo, Letícia B.; Scheeren, Laís E.; Mitjans Arnal, Montserrat; Infante Martínez-Pardo, Ma. Rosa; Rolim, Clarice M.B.; Vinardell Martínez-Hidalgo, Ma. Pilar
 

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