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Current directions in DNA gel particles
Morán Badenas, María del Carmen; Mitjans Arnal, Montserrat; Martínez Ocaña, Verónica; Nogueira, Daniele R.; Vinardell Martínez-Hidalgo, Ma. Pilar
Universitat de Barcelona
A general understanding of interactions between DNA andoppositely charged compounds forms the basis for developing novelDNA-based materials, including gel particles. The association strength,which is altered by varying the chemical structure of the cationiccosolute, determines the spatial homogeneity of the gelation process,creating DNA reservoir devices and DNA matrix devices that can bedesigned to release either single- (ssDNA) or double-stranded(dsDNA) DNA. This paper reviews the preparation of DNA gelparticles using surfactants, proteins and polysaccharides. Particlemorphology, swelling/dissolution behaviour, degree of DNAentrapment and DNA release responses as a function of the nature ofthe cationic agent used are discussed. Current directions in thehaemocompatible and cytotoxic characterization of these DNA gelparticles have been also included.
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/46988
2013-10-15
Investigació farmacèutica
Pharmaceutical research
(c) Transworld Research Network, 2013
info:eu-repo/semantics/bookPart
Transworld Research Network
         

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