dc.contributor.author
Amat Tusón, Mercedes
dc.contributor.author
Köver, Andrea
dc.contributor.author
Jokic, Danica
dc.contributor.author
Lozano, Oscar
dc.contributor.author
Pérez Bosch, Maria
dc.contributor.author
Landoni, Nicola
dc.contributor.author
Subrizi, Fabiana
dc.contributor.author
Bautista, Jesús
dc.contributor.author
Bosch Cartes, Joan
dc.date.issued
2015-01-08T18:30:18Z
dc.date.issued
2015-01-08T18:30:18Z
dc.date.issued
2015-01-08T18:30:19Z
dc.identifier
https://hdl.handle.net/2445/61086
dc.description.abstract
A straightforward synthesis of the Met antagonist JLK1360 involving an alkylationcyclocondensation process using aminothiazole 1 and nitrophenacyl bromide 2, reduction of the nitro group, and coupling of the resulting tetracyclic aniline 5 with an appropriate N-acyl alanine derivative, is reported.
dc.format
application/pdf
dc.publisher
Michigan Publishing
dc.relation
Reproducció del document publicat a: http://dx.doi.org/10.3998/ark.5550190.0011.313
dc.relation
Arkivoc, vol. 2010, núm. 3, p. 145-151
dc.relation
http://dx.doi.org/10.3998/ark.5550190.0011.313
dc.rights
cc-by-nc (c) Amat Tusón, Mercedes et al., 2010
dc.rights
http://creativecommons.org/licenses/by-nc/3.0/es
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject
Dianes farmacològiques
dc.subject
Proteïnes quinases
dc.subject
Transducció de senyal cel·lular
dc.subject
Drug targeting
dc.subject
Protein kinases
dc.subject
Cellular signal transduction
dc.title
Synthesis of a tetrahydroimidazo-[2',1':2,3]thiazolo[5,4-c]pyridine derivative with Met inhibitory activity
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
