Future prospects for Antimicrobial peptide development: peptidomimetics and antimicrobial combinations

Abstract

Antimicrobial resistance is widely recognized as one of the major challenges of public health worldwide, as infections by multidrug-resistant (MDR) bacteria have reached worrisome levels. Three levels of antibiotic resistance have been described [Citation1]: i) multi-resistance (resistance to at least three different families of antimicrobials), ii) extreme resistance (resistance to all antimicrobials except colistin) and iii) pan-drug resistance (resistance to all available antimicrobials).