Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer

Little is known regarding the interaction between immune microenvironment and tumorbiology in hormone receptor (HR)+/HER2− breast cancer (BC). We here assess pretreatmentgene-expression data from 66 HR+/HER2− early BCs from the LETLOB trial and show that non-luminal tumors (HER2-enriched, Basal-like) present higher tumor-infiltrating lymphocytelevels than luminal tumors. Moreover, significant differences in immune infiltrate composition,assessed by CIBERSORT, were observed: non-luminal tumors showed a more proinflammatoryantitumor immune infiltrate composition than luminal ones.

Document Type

Article

Published version

Language

English

Subjects and keywords

Càncer de mama; Receptors d'hormones; Antígens tumorals; Breast cancer; Hormone receptors; Tumor antigens

Publisher

Springer Nature

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Reproducció del document publicat a: https://doi.org/10.1038/s41523-021-00223-x

npj Breast Cancer, 2021, vol. 7, num.1

https://doi.org/10.1038/s41523-021-00223-x

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cc-by (c) Griguolo, Gaia et al., 2021

http://creativecommons.org/licenses/by/4.0/

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IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer [3164]

ISGlobal - Institut de Salut Global de Barcelona [60793]

Medicina [2834]