dc.contributor.author
Ficarra, Guido
dc.contributor.author
Prat Aparicio, Aleix
dc.contributor.author
Conte, Pierfranco
dc.contributor.author
Guarneri, Valentina
dc.contributor.author
Griguolo, Gaia
dc.contributor.author
Dieci, Maria Vittoria
dc.contributor.author
Paré, Laia
dc.contributor.author
Miglietta, Federica
dc.contributor.author
Generali, Daniele
dc.contributor.author
Frassoldati, Antonio
dc.contributor.author
Cavanna, Luigi
dc.contributor.author
Bisagni, Giancarlo
dc.contributor.author
Piacentini, Federico
dc.contributor.author
Tagliafico, Enrico
dc.contributor.author
Cagossi, Katia
dc.date.accessioned
2026-01-27T08:13:12Z
dc.date.available
2026-01-27T08:13:12Z
dc.date.issued
2026-01-26T12:45:00Z
dc.date.issued
2026-01-26T12:45:00Z
dc.date.issued
2021-02-12
dc.date.issued
2026-01-26T12:45:01Z
dc.identifier
https://hdl.handle.net/2445/226145
dc.identifier.uri
http://hdl.handle.net/2445/226145
dc.description.abstract
Little is known regarding the interaction between immune microenvironment and tumorbiology in hormone receptor (HR)+/HER2− breast cancer (BC). We here assess pretreatmentgene-expression data from 66 HR+/HER2− early BCs from the LETLOB trial and show that non-luminal tumors (HER2-enriched, Basal-like) present higher tumor-infiltrating lymphocytelevels than luminal tumors. Moreover, significant differences in immune infiltrate composition,assessed by CIBERSORT, were observed: non-luminal tumors showed a more proinflammatoryantitumor immune infiltrate composition than luminal ones.
dc.format
application/pdf
dc.publisher
Springer Nature
dc.relation
Reproducció del document publicat a: https://doi.org/10.1038/s41523-021-00223-x
dc.relation
npj Breast Cancer, 2021, vol. 7, num.1
dc.relation
https://doi.org/10.1038/s41523-021-00223-x
dc.rights
cc-by (c) Griguolo, Gaia et al., 2021
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Càncer de mama
dc.subject
Receptors d'hormones
dc.subject
Antígens tumorals
dc.subject
Hormone receptors
dc.subject
Tumor antigens
dc.title
Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
