Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons.

dc.contributor.author
Sancho Balsells, Anna
dc.contributor.author
Borràs Pernas, Sara
dc.contributor.author
Brito, Verónica
dc.contributor.author
Alberch i Vié, Jordi, 1959-
dc.contributor.author
Girault, Jean-Antoine
dc.contributor.author
Giralt Torroella, Albert
dc.date.issued
2024-02-15T15:23:32Z
dc.date.issued
2024-02-15T15:23:32Z
dc.date.issued
2023-02-14
dc.date.issued
2024-02-15T15:23:32Z
dc.identifier
1661-6596
dc.identifier
https://hdl.handle.net/2445/207574
dc.identifier
10.3390/ijms24043833
dc.identifier
742181
dc.identifier
36835243
dc.description.abstract
We found that specific manipulation of superficial but not deep pyramidal neurons of the CA1 resulted in the amelioration of depressive-like behaviors and the restoration of cognitive impairments induced by chronic stress. In summary, Egr1 might be a core molecule driving the activation/deactivation of hippocampal neuronal subpopulations underlying stress-induced alterations involving emotional and cognitive sequels.
dc.format
21 p.
dc.format
application/pdf
dc.format
application/pdf
dc.language
eng
dc.publisher
MDPI
dc.relation
Reproducció del document publicat a: https://doi.org/10.3390/ijms24043833
dc.relation
International Journal of Molecular Sciences, 2023, vol. 24, num.4
dc.relation
https://doi.org/10.3390/ijms24043833
dc.rights
cc-by (c) Sancho-Balsells A. et al., 2023
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Biomedicina)
dc.subject
Hipocamp (Cervell)
dc.subject
Neurones
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Memòria
dc.subject
Esquizofrènia
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Depressió psíquica
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Estrès (Psicologia)
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Hippocampus (Brain)
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Neurons
dc.subject
Memory
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Schizophrenia
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Mental depression
dc.subject
Stress (Psychology)
dc.title
Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons.
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion


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