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Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons.

Author

Sancho Balsells, Anna

Borràs Pernas, Sara

Brito, Verónica

Alberch i Vié, Jordi, 1959-

Girault, Jean-Antoine

Giralt Torroella, Albert

Publication date

2024-02-15T15:23:32Z

2024-02-15T15:23:32Z

2023-02-14

2024-02-15T15:23:32Z

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Abstract

We found that specific manipulation of superficial but not deep pyramidal neurons of the CA1 resulted in the amelioration of depressive-like behaviors and the restoration of cognitive impairments induced by chronic stress. In summary, Egr1 might be a core molecule driving the activation/deactivation of hippocampal neuronal subpopulations underlying stress-induced alterations involving emotional and cognitive sequels.

Document Type

Article

Published version

Language

English

Subjects and keywords

Hipocamp (Cervell); Neurones; Memòria; Esquizofrènia; Depressió psíquica; Estrès (Psicologia); Hippocampus (Brain); Neurons; Memory; Schizophrenia; Mental depression; Stress (Psychology)

Publisher

MDPI

Related items

Reproducció del document publicat a: https://doi.org/10.3390/ijms24043833

International Journal of Molecular Sciences, 2023, vol. 24, num.4

https://doi.org/10.3390/ijms24043833

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Rights

cc-by (c) Sancho-Balsells A. et al., 2023

http://creativecommons.org/licenses/by/4.0/

This item appears in the following Collection(s)

Biomedicina [779]

IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer [3164]

ISGlobal - Institut de Salut Global de Barcelona [60793]