Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons.

Fecha de publicación

2024-02-15T15:23:32Z

2024-02-15T15:23:32Z

2023-02-14

2024-02-15T15:23:32Z

Resumen

We found that specific manipulation of superficial but not deep pyramidal neurons of the CA1 resulted in the amelioration of depressive-like behaviors and the restoration of cognitive impairments induced by chronic stress. In summary, Egr1 might be a core molecule driving the activation/deactivation of hippocampal neuronal subpopulations underlying stress-induced alterations involving emotional and cognitive sequels.

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Artículo


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Inglés

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MDPI

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Reproducció del document publicat a: https://doi.org/10.3390/ijms24043833

International Journal of Molecular Sciences, 2023, vol. 24, num.4

https://doi.org/10.3390/ijms24043833

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Derechos

cc-by (c) Sancho-Balsells A. et al., 2023

http://creativecommons.org/licenses/by/4.0/