dc.contributor.author
Amat Tusón, Mercedes
dc.contributor.author
Subrizi, Fabiana
dc.contributor.author
Elias, Viviane
dc.contributor.author
Llor Brunés, Núria
dc.contributor.author
Molins, Elies
dc.contributor.author
Bosch Cartes, Joan
dc.date.issued
2020-06-04T08:27:34Z
dc.date.issued
2020-06-04T08:27:34Z
dc.date.issued
2020-06-04T08:27:34Z
dc.identifier
https://hdl.handle.net/2445/164259
dc.description.abstract
Starting from tricyclic lactam 2, which is easily accessible by cyclocondensation of -oxoester 1 with (R)-phenylglycinol, a three-step synthetic route to enantiopure 1-substituted tetrahydroisoquinolines, including 1-alkyl-, 1-aryl-, and 1-benzyl- tetrahydroisoquinoline alkaloids as well as the tricyclic alkaloid (-)-crispine A, has been developed. The key step is a stereoselective -amidoalkylation reaction using the appropriate Grignard reagent.
dc.format
application/pdf
dc.format
application/pdf
dc.relation
Versió postprint del document publicat a: https://doi.org/10.1002/ejoc.201200798
dc.relation
European Journal of Organic Chemistry, 2012, vol. 2012, num. 28, p. 5491-5497
dc.relation
https://doi.org/10.1002/ejoc.201200798
dc.rights
(c) Wiley-VCH, 2012
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject
Síntesi asimètrica
dc.subject
Asymmetric synthesis
dc.title
Stereoselective synthesis of cis-1,3-dimethyltetrahydroisoquinolines: formal synthesis of naphthylisoquinoline alkaloids
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/acceptedVersion
