dc.contributor.author
Bennasar Fèlix, M. Lluïsa
dc.contributor.author
Zulaica Gallego, Ester
dc.contributor.author
Solé Arjó, Daniel
dc.contributor.author
Roca Estrem, Tomàs
dc.contributor.author
García Díaz, Davinia
dc.contributor.author
Alonso Serrano, Sandra
dc.date.issued
2020-05-28T11:11:31Z
dc.date.issued
2020-05-28T11:11:31Z
dc.date.issued
2009-10-14
dc.date.issued
2020-05-28T11:11:32Z
dc.identifier
https://hdl.handle.net/2445/162821
dc.description.abstract
An indole-templated ring-closing metathesis or a 2-indolylacyl radical cyclization constitute the central steps of two alternative approaches developed to assemble the tricyclic ABC substructure of the indole alkaloid apparicine. From this key intermediate, an intramolecular vinyl halide Heck reaction accomplished the closure of the strained 1-azabicyclo[4.2.2]decane framework of the alkaloid with concomitant incorporation of the exocyclic alkylidene substituents.
dc.format
application/pdf
dc.publisher
American Chemical Society
dc.relation
Versió postprint del document publicat a: https://doi.org/10.1021/jo901986v
dc.relation
Journal of Organic Chemistry, 2009, vol. 74, p. 8359-8368
dc.relation
https://doi.org/10.1021/jo901986v
dc.rights
(c) American Chemical Society , 2009
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject
Síntesi orgànica
dc.subject
Metàtesi (Química)
dc.subject
Organic synthesis
dc.subject
Metathesis (Chemistry)
dc.title
Total Synthesis of the Brdged Indole Alkaloid Apparicine
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/acceptedVersion
