PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders

Research in recent years on peroxisome proliferator-activated receptor (PPAR)β/δ indicates that it plays a key role in the maintenance of energy homeostasis, both at the cellular level and within the organism as a whole. PPARβ/δ activation might help prevent the development of metabolic disorders, including obesity, dyslipidaemia, type 2 diabetes mellitus and non-alcoholic fatty liver disease. This review highlights research findings on the PPARβ/δ regulation of energy metabolism and the development of diseases related to altered cellular and body metabolism. It also describes the potential of the pharmacological activation of PPARβ/δ as a treatment for human metabolic disorders

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Homeòstasi; Obesitat; Diabetis; Metabolisme cel·lular; Farmacologia; Homeostasis; Obesity; Diabetes; Cell metabolism; Pharmacology

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MDPI

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Reproducció del document publicat a: https://doi.org/10.3390/ijms19030913

International Journal of Molecular Sciences, 2018, vol. 19, num. 3, p. 913

https://doi.org/10.3390/ijms19030913

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cc-by (c) Palomer Tarridas, Francesc Xavier et al., 2018

http://creativecommons.org/licenses/by/3.0/es

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